81049-29-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyrrolidinecarboxylic acid, ethyl ester, (-)-(9CI) is used as a synthetic intermediate for the development of chiral drugs. Its specific enantiomeric form is essential for the biological activity of the drugs, ensuring targeted therapeutic effects and minimizing side effects.
Used in Agrochemical Industry:
3-Pyrrolidinecarboxylic acid, ethyl ester, (-)-(9CI) may have potential applications in the development of new pesticides and herbicides. Its chiral nature allows for the creation of enantioselective agrochemicals, which can target specific pests or weeds while minimizing harm to non-target organisms and the environment.

InChI:InChI=1/C7H13NO2/c1-2-10-7(9)6-3-4-8-5-6/h6,8H,2-5H2,1H3

Upstream product

• 140-88-5 ethyl acrylate 
• 10603-52-8 1-benzyl-pyrrolidine-3-carbonitrile 
• 59378-87-9 pyrrolidine-3-carboxylic acid 
• 64-17-5 ethanol 
• 5747-92-2 1-benzyl-3-carboethoxypyrrolidine 
• 29897-82-3 N-benzylpyrrolidine 

Downstream Products

• 1258281-39-8 2-[2-chloro-5-(3-ethoxycarbonyl-pyrrolidin-1-yl)-phenyl]-5-methyl-benzoimidazole-1-carboxylic acid tert-butyl ester 
• 5747-92-2 1-benzyl-3-carboethoxypyrrolidine 
• 5731-18-0 1-benzyl-pyrrolidine-3-carboxylic acid 

Relevant academic research and scientific papers

Discovery of novel n-substituted prolinamido indazoles as potent rho kinase inhibitors and vasorelaxation agents

Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma. In a previous article, we described the lead discovery of DL0805, a new ROCK I inhibitor, showing potent inhibitory activity (IC50 6.7 μM). Herein, we present the lead optimization of compound DL0805, resulting in the discovery of 24- and 39-fold more-active analogues 4a (IC50 0.27 μM) and 4b (IC50 0.17 μM), among other active analogues. Moreover, ex-vivo studies demonstrated that 4a and 4b exhibited comparable vasorelaxant activity to the approved drug fasudil in rat aortic rings. The research of a preliminary structure-activity relationship (SAR) indicated that the target compounds containing a β-proline moiety have improved activity against ROCK I relative to analogues bearing an β-proline moiety, and among the series of the derivatives with a β-proline-derived indazole scaffold, the inhibitory activity of the target compounds with a benzyl substituent is superior to those with a benzoyl substituent.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Pyrrolidines

This invention relates to a class of pyrrolidine compounds of formula (I), and pharmaceutically acceptable derivatives thereof, to their use in medicine, to compositions containing them, and to processes for their preparation. It also relates to intermedi

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I) wherein A is formula (II), formula (III) or formula (IV), and B is formula (V), formula (VI), or formula (VII), can be used in a variety of applications including use as antibacterial agents.

ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES

Compounds of formula (I) wherein: A is Formula (II), Formula (III), or Formula (IV) and B is Formula (V), Formula (VI), or Formula (VII), can be used in a variety of applications including use as antibacterial agents.

1-(4-PIPERIDINYL) BENZIMIDAZOLONES AS HISTAMINE H3 ANTAGONISTS

Disclosed are histamine H3 antagonists of the formula (I) wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined

Oxadiazoles useful in the treatment of senile dementia

A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring, and substituted on the other ring carbon atom with a substituent of low lipophilicity; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses.

THIADIAZOLES USEFUL IN THE TREATMENT OF SENILE DEMENTIA

A class of novel thiadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring system, and substituted on the other ring carbon atom with a substituent of low lipophilicity, or a hydrocarbon substituent; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses, and are also of benefit in the treatment of severe painful conditions.

β-Proline Analogues as Agonists at the Strychnine-Sensitive Glycine Receptor

3-Carboxy-3,4-dehydropyrrolidine was found to bind with affinity equal to that of glycine in a strychnine binding assay.Simple substitution of the 1-, 2-, 4-, or 5-position resulted in marked loss of affinity.A decaline in affinity was also found upon