81067-37-0

Usage

Uses

Used in Chemical Synthesis:
1-Bromo-2,3,4-trichlorobenzene is used as an intermediate in the synthesis of various chemical compounds. Its unique structure allows it to be a key component in the production of a range of products.
Used in the Production of Fluoro-PCBs:
1-Bromo-2,3,4-trichlorobenzene is utilized in the synthesis of monofluorinated polychlorinated biphenyls (fluoro-PCBs). These fluoro-PCBs have potential applications in various industries, such as in the manufacturing of electrical equipment and as heat transfer agents.
Used as Internal Standards for PCB Analysis:
In the field of environmental and analytical chemistry, 1-Bromo-2,3,4-trichlorobenzene serves as an internal standard for the analysis of polychlorinated biphenyls (PCBs). Its consistent and stable properties make it an ideal reference point for accurate PCB measurements and analysis, ensuring reliable results in research and monitoring efforts.

Upstream product

• 634-67-3 2,3,4-trichloroaniline 
• 87-61-6 1,2,3-trichlorobenzene 
• 811720-26-0 1,5-dibromo-2,3,4-trichlorobenzene 
• 915144-98-8 2,3,4-trichloro-1,5-phenylenebis(trimethylsilane) 
• 915144-97-7 trimethyl(2,3,4-trichlorophenyl)silane 

Downstream Products

• 154257-75-7 2,4-difluoro-3-chlorobenzoic acid 
• 887267-38-1 3-chloro-2,4-difluorobenzonitrile 
• 2112-31-4 2,3,4-tri-chloro-benzonitrile 
• 21928-51-8 5-bromo-1,2,3-trichloro-benzene 

Relevant academic research and scientific papers

Synthesis method of 3-chloro-2,4-difluorobenzoic acid

The invention relates to a synthesis method of 3-chloro-2,4-difluorobenzoic acid. The method comprises: taking 1,2,3-trichlorobenzene and N-bromosuccinimide to react, taking CuCN and 1-bromo-2,3,4-trichlorobenzene to react, taking the 1-bromo-2,3,4-trichlorobenzene and KF to react and taking 3-chloro-2,4-difluorobenzonitrile and sulfuric acid to react, so as to form the 3-chloro-2,4-difluorobenzoic acid. According to the synthesis method, synthesis reaction conditions are that a reaction is carried out at normal pressure and reaction temperature fluctuates between 0 and 250 DEG C; the obtained finished product is a light yellow powdery solid and the content is more than or equal to 99.0 percent; the total mol yield of the 3-chloro-2,4-difluorobenzoic acid can reach 61.5 percent; whole reaction conditions are moderate and the method is convenient to operate and control; pressure of waste gas, waste water and waste residues is relatively low so that industrial production is facilitated.

PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE

The present invention relates to a process for the preparation of a compound of formula I (I), comprising reacting a compound of formula II (II), with a brominating agent in the presence of an acidic catalyst to a compound of formula III (III), and reacti

Tribromoisocyanuric acid in trifluoroacetic acid: An efficient system for smooth brominating of moderately deactivated arenes

Moderately deactivated arenes are efficiently brominated by the reaction with tribromoisocyanuric acid (0.34 mol equiv) in trifluoroacetic acid at room temperature in 48-85% isolated yield. This medium avoids the polybromination of the substrate, observed in the same reaction performed in 98% H 2SO4. Georg Thieme Verlag Stuttgart · New York.

Synthesis of dioxin-like monofluorinated PCBs: for the use as internal standards for PCB analysis

Monofluorinated polychlorinated biphenyls (fluoro-PCBs) have been prepared using the Suzuki-coupling, for use as analytical standards for PCB measurements. Seven of these fluoro-PCBs are analogues of the dioxin-like PCBs, listed by the WHO as the most toxic PCB congeners. Four highly chlorinated fluoro-PCBs have been prepared by Suzuki-coupling of 2,3,5,6-tetrachloro-bromoaniline with various substituted arylboronic acids. The resulting amino-fluoro-PCBs are chlorinated using the Sandmeyer reaction or deaminated to yield tetra-, penta- and hexa-chlorinated fluoro-PCBs. The fluoro-PCBs elute just before the corresponding PCBs in the GC chromatogram, which strongly indicates their potential as analytical standards.

Proton mobility in 2-substituted 1,3-dichlorobenzenes: "ortho" or "meta" metalation?

Nine 1,3-dichlorobenzene congeners were selected as model compounds to assess the relative rates of proton abstraction from 4- and 5-positions ("ortho" vs. "meta" metalation). Using lithium 2,2,6,6-tetramethylpiperidide as the basic reagent, the chlorine-adjacent 4-position underwent metalation exclusively. In contrast, attack at the chlorine-remote 5-posi" tion became significant even in the case of moderately sized 2-substituents (such as dimethylamino or ethyl) when secbutyllithium was employed. The "ortho/para" (4-/5-) ratios ranged from 80:20 to 65:35. The more pronounced "meta-orienting" effect of silicon as opposed to carbon substituents can be attributed to dissimilarities in the n polarization of the aromatic ring. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.