81073-28-1

Upstream product

• 591-50-4 iodobenzene 
• 179015-82-8 diethyl 1-(ethoxyphosphinyl)methylphosphonate 
• 17763-67-6 Phenyl triflate 
• 108-86-1 bromobenzene 
• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 64-17-5 ethanol 
• 683-08-9 Diethyl methylphosphonate 
• 3167-63-3 diethyl chloromethylphosphonate 
• 1638-86-4 diethyl phenylphosphonite 

Downstream Products

• 84181-72-6 (E)-(1-butenyl)(ethoxy)(phenyl)phosphine oxide 
• 145082-49-1 phosphonic acid 
• 81073-10-1 diethyl 3-methyl-2-butenylphosphonate 
• 1018-24-2 diethyl styrylphosphonate 
• 82943-05-3 (E)-(phenyl)(2-phenylethyl)(ethoxy)phosphine oxide 
• 145082-65-1 (S/R)-diethylphosphonate 

Relevant academic research and scientific papers

A simple and efficient preparation of (arylphosphinyl)methylphosphonates

A simple and efficient preparation of (arylphosphinyl)methylphosphonates is described whereby the phosphinylmethylphosphonate group is introduced via the Pd(O) mediated phosphinylation of an aryl halide or triflate with diethyl (ethoxyphosphinyl)methylphosphonate.

Synthesis of P-chiral enephosphonic acid derivatives

An efficient and convenient synthesis of chiral enephosphonic acid derivatives (enephosphonates, enephosphonamides, enephosphinates) was reported by a two-step procedure involving alkylidenediphosphorylation of nucleophiles followed by a Horner-Emmons olefination. Depending on the selected strategy, the synthesis could be executed according to a one-pot or a twostep reaction sequence. Regioselectivity of Horner-Emmons reaction and 31P-NMR study of diphosphorylated anions were described.

α-Halo phosphonates as Specific Inhibitors of Na+-Gradient-Dependent Na+-Phosphate Cotransport across Renal Brush Border Membrane

Certain phosphonocarboxylate analogues of phosphate are known to inhibit Na+-phosphate (Pi) cotransport in renal brush border membrane (BBM), but previously tested potential inhibitors incorporating structurally versatile aryl functi