81096-49-3Relevant academic research and scientific papers
Method for synthesizing polysubstituted alpha, beta unsaturated ketones
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Paragraph 0044-0048, (2020/03/06)
The invention particularly relates to a method for synthesizing polysubstituted alpha, beta unsaturated ketones. The method comprises the following steps: 1, adding Ni(cod), an N-heterocyclic carbene ligand, Cs2CO3 and a beta, gamma unsaturated ketone into a non-polar aprotic organic solvent, and mixing to obtain a mixture; 2, adding the mixture obtained in the step 1 into a dried container, reacting for 10-40 hours at the reaction temperature of 120-180 DEG C, and cooling to room temperature after the reaction is finished, so as to obtain a crude product; 3, purifying. According to the method, cheap Ni(cod) is adopted as a catalyst, carbon-carbon bonds are activated by a transition metal, power is provided for the reaction through isomerization of double bonds, the synthesis methodis simple, the substrates are stable and cheap, the reaction is less limited by the substrate, and the substrates are wide in application range.
Ni-Catalyzed 1,2-Acyl Migration Reactions Triggered by C-C Bond Activation of Ketones
Jiang, Cheng,Lu, Hong,Xu, Wen-Hua,Wu, Jianing,Yu, Tian-Yang,Xu, Peng-Fei,Wei, Hao
, p. 1947 - 1953 (2020/02/06)
A Ni-catalyzed 1,2-acyl migration triggered by C-C bond cleavage was developed. The process of 1,2-acyl migration followed by olefin isomerization provides a convenient access to α,β-unsaturated ketones, which are well-known building blocks in organic syn
Palladium-catalyzed alkenylation of ketone enolates under mild conditions
Grigalunas, Michael,Ankner, Tobias,Norrby, Per-Ola,Wiest, Olaf,Helquist, Paul
supporting information, p. 3970 - 3973 (2014/08/18)
A protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates has been developed using a Pd/Q-Phos catalyst. Efficient intermolecular coupling of a variety of ketones with alkenyl bromides was achieved with a slight excess of LiHMDS and temperatures down to 0 °C.
