81111-93-5

Basic information

• Product Name: 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal
• Synonyms: 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal
• CAS NO: 81111-93-5
• Molecular Weight: 350.436
• Mol File: 81111-93-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal(81111-93-5)
• EPA Substance Registry System: 1-phenyl-2-(p-toluenesulfonyloxy)-1-propanone dimethyl acetal(81111-93-5)

Safety Data

• Hazardous Substances Data: 81111-93-5(Hazardous Substances Data)

Upstream product

• 73611-99-1 2-Hydroxypropiophenone dimethylacetal 
• 98-59-9 p-toluenesulfonyl chloride 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 87456-64-2 α-tosyloxypropiophenone 
• 149-73-5 trimethyl orthoformate 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 6493-83-0 2-methoxy-1-phenyl-propan-1-one 
• 31508-44-8 2-phenylpropionic acid methyl ester 

Relevant articles and documents

General Method for the Preparation of Electron-Deficient Imidazo[1,2-a]pyridines and Related Heterocycles

A new annulation method for the preparation of the imidazo[1,2-a]pyridine ring system under mild conditions is presented. Treatment of a 2-aminopyridine with a dimethylketal tosylate in acetonitrile at elevated temperature (80-140°C) in the presence of catalytic Sc(OTf)3 provides the imidazo[1,2-a]pyridine product in good yield. The annulation method is broadly applicable to electron-poor 2-aminopyridines and displays a complementary profile to the classic preparation of the imidazo[1,2-a]pyridine ring system by reaction of a bromoketone with electron-rich and -neutral substrates. The scope of the process and mechanistic considerations are discussed.