Tetrahedron p. 1661 - 1667 (2017)
Update date:2022-08-05
Topics:
Adeyemi, Christiana M.
Isaacs, Michelle
Mnkandhla, Dumisani
Klein, Rosalyn
Hoppe, Heinrich C.
Krause, Rui W.M.
Lobb, Kevin A.
Kaye, Perry T.
Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle.
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