81187-88-4

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 106-39-8 bromochlorobenzene 
• 99-91-2 para-chloroacetophenone 
• 124-38-9 carbon dioxide 
• 45941-96-6 2-(4-chlorophenyl)-3-hydroxypropene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 89220-51-9 α-bromomethyl-4-chlorostyrene 
• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 

Downstream Products

• 218292-25-2 methyl 3-(4-chlorophenyl)-3-butenoate 
• 1254470-60-4 N-[2-(4-chlorophenyl)prop-2-en-1-yl]-N-(p-toluenesulfonyl)amide 
• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 1374016-18-8 N-[2-(4-chlorophenyl)prop-2-en-1-yl]-N,N-bis(p-toluenesulfonyl)imide 
• 218292-39-8 (R)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-chloro-phenyl)-morpholine-4-carboxylic acid tert-butyl ester 
• 218292-33-2 (R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-butane-1,2-diol 
• 218292-30-9 tert-Butyl-[3-(4-chloro-phenyl)-but-3-enyloxy]-dimethyl-silane 
• 29123-92-0 3-(4-chlorophenyl)but-3-en-1-ol 

Relevant academic research and scientific papers

Highly Regioselective Palladium-Catalyzed Carboxylation of Allylic Alcohols with CO2

Various allylic alcohols were carboxylated in the presence of a catalytic amount of PdCl2 and PPh3 using ZnEt2 as a stoichiometric transmetalation agent under a CO2 atmosphere (1atm). This carboxylation proceeded in a highly regioselective manner to afford branched carboxylic acids predominantly. The β,γ-unsaturated carboxylic acid thus obtained was successfully converted into an optically active γ-butyrolactone, a known intermediate of (R)-baclofen.

Direct carboxylation of allylic halides with carbon dioxide in the presence of indium

A highly regioselective indium-mediated allylation of carbon dioxide starting from simple allylic halides (X = I, Br, Cl) has been developed. No transition metal catalyst is needed and an inert atmosphere is not necessary. The reaction tolerates a wide range of synthetically attractive functional groups with a very high branched regioselectivity. The Royal Society of Chemistry 2014.

Rh-catalyzed highly enantioselective synthesis of 3-arylbutanoic acids

(Chemical Equation Presented) It's in the mix: The reaction conditions - catalyst, additive, and solvent - have been optimized for the asymmetric hydrogenation of 3-aryl-3-butenoic acids. The rigid, chiral bisphospholane ligand (SP,RC)-DuanPhos is crucial to achieving high enantioselectivity.

An efficient synthesis of enantiomerically pure 2-[(2R)-arylmorpholin- 2-yl]ethanols, key intermediates of tachykinin receptor antagonist

We report herein an efficient and practical synthetic method for the preparation of enantiomerically pure 2[(2R)-arylmorpholin-2-yl]ethanols 1a- d, key intermediates of tachykinin receptor antagonist. Sharpless catalytic asymmetric dihydroxylation of 4a-d was employed to introduce the required absolute stereochemistry, and cyclization of 7a-d was accomplished by the Mitsunobu reaction.