147224-51-9

Basic information

• Product Name: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4R)-
• CAS NO: 147224-51-9
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.633
• Mol File: 147224-51-9.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4R)-(147224-51-9)
• EPA Substance Registry System: 2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4R)-(147224-51-9)

Safety Data

• Hazardous Substances Data: 147224-51-9(Hazardous Substances Data)

Usage

General Description

2(3H)-Furanone, 4-(4-chlorophenyl)dihydro-, (4R)- is a chemical compound that is also known as Sulfurol. It is a colorless to pale yellow liquid with a sweet, fruity odor. Sulfurol is commonly used as a flavoring agent in the food industry, particularly in baked goods and confectionery. It can also be found in some cosmetic and personal care products. The chemical is synthesized from various starting materials, including furfuryl alcohol and 4-chlorophenylacetic acid. Sulfurol is considered safe for use in food and cosmetics when used in accordance with regulations and guidelines.

Upstream product

• 91154-08-4 2-(4-Chloro-phenyl)-butane-1,4-diol 
• 1679-18-1 4-Chlorophenylboronic acid 
• 902154-51-2 γ-acetoxycrotonic acid tert-butyl ester 
• 98272-71-0 γ-acetoxycrotonic acid methyl ester 
• 497-23-4 2-buten-4-olide 
• 52977-95-4 3-(p-chlorophenyl)-4-hydroxybutyric acid 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 201230-82-2 carbon monoxide 
• 191019-76-8 2,2-dichloro-3-(4'-chlorophenyl)cyclobutanone 
• 1073-67-2 4-vinylbenzyl chloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 152714-07-3 3-(4-chlorophenyl)cyclobutanone 
• 476471-06-4 4-(4-chlorophenyl)-2-methoxytetrahydrofuran 
• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 

Downstream Products

• 89359-16-0 (S)-β-(4-chlorophenyl)-γ-butyrolactone 
• 147224-53-1 (R)-ethyl 4-azido-3-(4-chlorophenyl)-1-butanoate 
• 188635-62-3 (R)-4-Azido-3-(4-chloro-phenyl)-butyric acid 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 188635-61-2 (R)-3-(4-Chloro-phenyl)-4-iodo-butyric acid ethyl ester 
• 185342-39-6 5-Bromo-4-(4-chloro-phenyl)-5H-furan-2-one 
• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 

Relevant articles and documents

An efficient synthesis of (R)-(-)-baclofen

In this report we describe an efficient synthesis of (R)-(-)-baclofen, a selective GABA(B) agonist used as an antispastic agent. Our strategy is based on an enantioselective deprotonation of a cyclobutanone easily obtained by [2+2] cycloaddition of 4-chlorostyrene and dichloroketene.

Synthesis method of butyrolactone compound

The invention relates to a synthesis method of a butyrolactone compound. The synthesis method comprises the following step: in the presence of a solvent and a cobalt catalyst, converting an oxetane compound shown as general formula I into a butyrolactone compound shown as general formula II through carbonyl insertion ring expansion reaction in an atmosphere of CO and H2. Compared with an existingmethod for synthesizing butyrolactone through oxetane carbonylation ring expansion reaction in a carbon monoxide atmosphere, the synthesis method of a butyrolactone compound provided by the inventionhas the advantages of excellent catalytic activity, excellent chemical selection, wide substrate applicability, mild reaction conditions and the like; compared with other methods for synthesizing butyrolactone compounds, the method provided by the invention has the advantages of wide substrate range, high atom economy, no need of noble metal catalysis and the like, therefore the method has a wideapplication prospect.

Determination of the absolute configuration of two αvβ6 integrin inhibitors for the treatment of idiopathic pulmonary fibrosis and investigations on the asymmetric 1,4-addition of arylboronic acids to crotonate esters bearing a C4-oxygen substituent

The absolute configuration of two novel αvβ6 integrin inhibitors was established via degradation to the corresponding C3-aryl substituted butyrolactone. The configuration of the resulting lactones was established by asymmetric synthesis using 1,4-addition of arylboronic acids to butenolide, catalysed by bis(norbornadiene)rhodium (I) tetrafluoroborate in the presence of (R)-BINAP, and confirmed by X-ray crystallography. Studies on arylboronic acid conjugate additions to acyclic crotonate esters bearing a γ-oxygen substituent are also reported. Three Rh catalysts were investigated and the one giving the highest enantioselectivity was bis(norbornadiene)rhodium (I) tetrafluoroborate.