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Usage

Uses

Used in Organic Synthesis:
1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structural features allow for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE is utilized as a starting material or a building block in the development of new drugs. Its potential to form biologically active compounds makes it a valuable asset in medicinal chemistry for the design and synthesis of pharmaceutical agents.
Used in Drug Development:
1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE is employed as a molecular scaffold in drug development, where its benzyloxy and fluorine substituents may impart specific pharmacological properties. This allows researchers to explore its potential in creating new drugs with targeted therapeutic effects.
Used in Medicinal Chemistry:
In medicinal chemistry, 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE is used for the synthesis of compounds with potential therapeutic applications. Its unique structural elements make it a promising candidate for the development of novel pharmaceutical agents with improved efficacy and selectivity.

InChI:InChI=1/C15H13FO2/c1-11(17)13-7-8-15(14(16)9-13)18-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3

Upstream product

• 403-14-5 3-fluoro-4-hydroxyacetophenone 
• 100-39-0 benzyl bromide 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 133057-82-6 1-benzyloxy-4-bromo-2-fluorobenzene 
• 367-12-4 2-fluorophenol 
• 2105-94-4 4-bromo-2-fluorophenol 

Downstream Products

• 73898-27-8 1-(4-benzyloxy-3-fluorophenyl)-2-bromoethanone 
• 1071167-55-9 2-(4-(benzyloxy)-3-fluorophenyl)-2-methyl-1,3-dioxolane 
• 1042702-48-6 2-(4-benzyloxy-3-fluorophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 
• 1042702-50-0 4-(2-(3-fluoro-4-hydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 
• 1292298-83-9 4-(2-(4-hydroxy-3-nitrophenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 
• 1290181-30-4 methyl 3-(4-(benzyloxy)-3-fluorophenyl)-3-oxopropanoate 
• 73898-42-7 4-(2-Amino-1-hydroxy-ethyl)-2-fluoro-phenol; hydrochloride 
• 177782-02-4 Acetic acid 4-benzyloxy-3-fluoro-phenyl ester 

Relevant academic research and scientific papers

Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

PESTICIDAL SUBSTITUTED PHENYLETHERS

The invention relates to the use of phenylether derivatives of formula (I), to compositions thereof for the control of pests, including arthropods and helminths.

SUBSTITUTED PHENOXY-AMINOPROPANOLS

Substituted phenoxy-aminopropanols of the formula STR1 wherein R is a branched-chain alkyl of 3 or 4 carbon atoms, R 1 is hydrogen, halogen or lower alkyl and R 2 and R 3, independently, are hydrogen, halogen, lower alkyl, lower alkoxy or lower alkylthio, and pharmaceutically acceptable acid addition salts thereof, are described. A process for their preparation, as well as pharmaceutical preparations containing them are also described. The compounds of formula I and their salts possess cardioselective β-adrenergic blocking activity and antihypertensive activity.

β1-Selective Adrenoceptor Antagonists. 2. 4-Ether-Linked Phenoxypropanolamines

A series of 4-substituted phenoxypropanolamines was prepared and examined for β-adrenoceptor activity.Some of the compounds, especially the oxy>ethoxy>phenoxy>propanolamines (14, 15, and 24), showed potent β1-blo