81352-25-2

Basic information

• Product Name: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE
• Synonyms: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE;5'-O-DMT-adenosine;Adenosine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine
• CAS NO: 81352-25-2
• Molecular Formula: C₃₁H₃₁N₅O₆
• Molecular Weight: 569.60774
• Mol File: 81352-25-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 145-147 °C
• Boiling Point: 812.0±75.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 13.08±0.70(Predicted)
• CAS DataBase Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE(81352-25-2)
• EPA Substance Registry System: 5'-O-(4,4'-DIMETHOXYTRITYL)ADENOSINE(81352-25-2)

Safety Data

• Hazardous Substances Data: 81352-25-2(Hazardous Substances Data)

Usage

Uses

5''-O-[Bis(4-methoxyphenyl)phenylmethyl]-adenosine is an oligonucleotide used in the synthesis of oligonucleotides carrying fluorescently labeled O6-alkylguanine for measuring hAGT activity.

Upstream product

• 17331-18-9 N'-[9-((3aR,4R,6R,6aR)-2-Dimethylamino-6-hydroxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl]-N,N-dimethyl-formamidine 
• 58-61-7 adenosine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 58-61-7 adenosine 
• 219677-67-5 5'-O-dimethoxytrityl-2'-O,3'-O,6-N-triphenoxyacetyladenosine 
• 121058-83-1 5′-O-(dimethoxytrityl)-2′-O-(tert-butyldimethylsilyl)-N⁶-phenoxyacetyladenosine 
• 6216-67-7 Adenosin-5'-phosphorsaeure-(N-benzyloxycarbonyl-L-leucinolat) 
• 1054645-97-4 Phenoxy-acetic acid (2R,3R,4R,5R)-5-[((S)-2-benzyloxycarbonylamino-4-methyl-pentyloxy)-hydroxy-phosphoryloxymethyl]-4-(2-phenoxy-acetoxy)-2-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 
• 1054613-08-9 C₃₅H₃₃N₅O₈ 
• 151928-74-4 5'-O-(4,4'-dimethoxytrityl)-2',3'-bis-O-acetyl-adenosine 
• 1446484-46-3 (S)-(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-3-yl 2-((tert-butoxycarbonyl)amino)-4-(phenyldisulfanyl)butanoate 
• 1446484-45-2 (S)-(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-3-yl 2-((tert-butoxycarbonyl)amino)-4-(tert-butyldisulfanyl)butanoate 
• 1446484-44-1 (S)-(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-3-yl 2-((tert-butoxycarbonyl)amino)-4-(isopropyldisulfanyl)butanoate 

Relevant articles and documents

Synthesis and preliminary evaluation of pro-RNA 2′- O -masked with biolabile pivaloyloxymethyl groups in an RNA interference assay

The cellular delivery of bioactive nucleic acid-based drugs such as small interfering RNA (siRNA) represents a major technical hurdle for their pharmaceutical application. Prodrug-like approaches provide an attractive concept to address the delivery probl

A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides

A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.

Tetrabutylammonium bromide: An efficient media for dimethoxytritylation of the 5'-hydroxyl function of nucleosides

An efficient procedure for selective dimethoxytritylation of the 5'-hydroxyl function of nucleosides in the presence of DABCO in molten tetrabutylammonium bromide is described. The methodology is very practical, environmentally benign and produced the desired product in less than 5 min by grinding in a hot mortar. In addition, the effects of the room temperature ionic liquid (1-butyl-3-methylimidazolium chloride) and microwave irradiation on this system were also studied and the results showed that depurination of the nucleosides occurred under microwave irradiation.