81382-49-2

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 872-35-5 1,3-dihydro-imidazole-2-thione 

Downstream Products

• 81382-51-6 Pentiapine 
• 81382-65-2 1-<2-(2-imidazolyl)thiophenyliminocarbonyl>-4-methylhomopiperazine 
• 81382-54-9 1-<2-(2-imidazolyl)thiophenyliminothiocarbonyl>-4-methylpiperazine 
• 81382-55-0 1-<2-(2-imidazolyl)thiophenyliminocarbonyl>-4-methylpiperazine 
• 81382-50-5 2-[(2-Aminophenyl)thio]-1H-imidazole 

Relevant academic research and scientific papers

5(1-Piperazinyl(imidazo[2,1-b][1,3,5]benzothiadiazepines

5-Diazacycloalkyl-imidazo[2,1-b][1,3,5]benzothiadiazepines, e.g. those of the formula STR1 the N-oxides and salts thereof are neuroleptic agents, lacking extrapyramidal side-effects.

Imidazole systems. I. Imidazo[2,1 b][1,3,5]benzothiadiazepine derivatives as potential antipsychotic agents

Imidazo[2,1-b][1,3,5]benzothiadiazepine 3 constitutes a novel ring system, and its analogs 3a-i were synthesized to investigate their potential antipsychotic activity. The synthesis of the ring system was achieved by reaction of 2-aminophenylthioimidazoles 7 with phosgene or thiophosgene and by ring closure of the 1-[2-(2-imidazolyl)thiophenyliminocarbonyl]-1 piperazines 13. An efficient method for the conversion of thioureas 8, 12 to guanidine 3a via the corresponding cyanothioamidines 11, 14 was developed.