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Upstream product

• 1779-81-3 4,5-Dihydro-thiazol-2-ylamin 
• 7440-44-0 pyrographite 
• 4192-77-2 ethyl cinnamate 
• 100-52-7 benzaldehyde 
• 136498-04-9 5-Oxo-7-phenyl-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester 
• 102-92-1 Cinnamoyl chloride 
• 102-92-1 cinnamoyl chloride 

Relevant academic research and scientific papers

New thiazolopyrimidine derivatives, synthesis and structure-activity relationships

Twenty-six derivatives of 5- and 7-oxo or 5- and 7-aminothiazolopyrimidines were prepared and evaluated as positive inotropic, anti-inflammatory and antihypertensive agents both in vitro and in vivo.The structures of the 5- and 7-isomers have been confirmed unambiguously by IR, UV, 1H and 13C NMR and MS.The structure of 1a was confirmed by the synthesis of compound 1 whose structure had been previously established by X-ray analysis.The 5-aminothiazolo-pyrimidine-6-carbonitrile derivatives 5a and 5e exhibited potent inotropic activities. 5e was more potent thanthe classical reference amrinone.Three compounds 5e, 5i and 5j displayed moderate antihypertensive activities.The 4-chlorophenyl derivative 5d exhibited an anti-inflammatory activity 2-fold that of aspirin.This study has demonstrated that thiazolopyrimidine compounds have interesting biological potentialities, particularly as inotropic agents, a field which had never been explored so far for this series. thiazolopyrimidines / cardiotonic / inotropic / antihypertensive / anti-inflammatory activity

One-pot synthesis of thiazolidino [3,2-a] pyrimidine derivatives

Reaction of 2-aminothiazoline with an aromatic aldehyde and an activated methylene group (malonitrile, diethylmalonate or ethylcyanoacetate) gave the title compounds. The structures are unambiguously assigned using spectroscopic data and chemical proofs.

2,3,6,7-Tetrahydrothiazolo[3,2-a]pyrimidine derivatives having anti-rheumatic properties and pharmaceutical compositions containing them

Thiazolo[3,2-a]pyrimidine derivative of the formula: STR1 wherein R represents phenyl, alkyl of 1 through 4 carbon atoms, alkyl of 1 through 4 carbon atoms substituted by 1 through 3 halogen atom, alkenyl of 2 through 4 carbon atoms, or cycloalkyl of 3 th