81593-59-1

Upstream product

• 64880-89-3 N-[(3-methoxyphenyl)ethyl]-4′′-methylbenzenesulfonamide 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 81593-56-8 [[2-(3-Methoxy-phenyl)-ethyl]-(toluene-4-sulfonyl)-amino]-acetic acid 
• 81593-57-9 7-methoxy-3-(4-methylphenylsulfonyl)-2,3,4,5-tetrahydro-3-benzazepin-1-one 

Downstream Products

• 81593-60-4 1,2-dihydro-8-methoxy-3-(p-toluenesulfonyl)-3H-3-benzazepine 
• 50351-80-9 7-methoxy-2,3,4,5-tetrahydro-1H-benz[d]azepine 
• 81593-61-5 1,2,4,5-tetrahydro-7-methoxy-3-(p-toluenesulfonyl)-3H-3-benzazepine 
• 81593-50-2 3,4-Dimethoxy-benzoic acid 4-(7-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl ester; hydrochloride 
• 1229622-10-9 3-{3-[2-(4-tert-butylphenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-propyl}-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol 
• 1229622-25-6 1-(4-tert-butylphenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)butane-1-one 
• 1229622-12-1 3-{3-[2-(4-fluorphenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl}-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol 
• 1229622-05-2 7-methoxy-3-[3-(phenylsulfanyl)propyl]-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol 
• 1229622-08-5 7-methoxy-3-[4-(phenylsulfanyl)butyl]-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol 
• 1229622-13-2 1-(4-fluorophenyl)-4-(1-hydroxy-7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine-3-yl)-butane-1-one 
• 1229622-07-4 7-methoxy-3-(5-phenylpentyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol 
• 1253197-18-0 trans-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol 
• 1253197-19-1 cis-7-methoxy-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1-ol 
• 1232196-73-4 WMS-1405 

Relevant academic research and scientific papers

NR2B SELECTIVE NMDA-RECEPTOR ANTAGONISTS FOR TREATMENT OF IMMUNE-MEDIATED INFLAMMATORY DISEASES

The present invention provides novel means and methods for treatment auf immunemediated inflammatory diseases.

Design, synthesis, and biological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagonists

Cleavage and reconstitution of a bond in the piperidine ring of ifenprodil (1) leads to 7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols, a novel class of NR2B-selective NMDA receptor antagonists. The secondary amine 7-methoxy-2,3,4,5-tetrahydro-1H-3-be

NR2B-SELECTIVE NMDA-RECEPTOR ANTAGONISTS

The present invention relates to compounds according to general formula (I) and pharmaceutical compositions comprising compounds according to general formula (I).