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Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-AMINO-4-METHYLPYRIMIDINE-5-CARBOXYLATE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure allows for the development of new drugs with improved therapeutic properties and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, ETHYL 2-AMINO-4-METHYLPYRIMIDINE-5-CARBOXYLATE serves as a building block for the creation of novel agrochemicals. Its incorporation into the molecular structure of these compounds can enhance their effectiveness in controlling pests and diseases, while minimizing the environmental impact.
Used in Antimicrobial Applications:
ETHYL 2-AMINO-4-METHYLPYRIMIDINE-5-CARBOXYLATE is used as an antimicrobial agent for its potential antifungal and antibacterial properties. Its incorporation into various formulations can help combat microbial infections and reduce the spread of antibiotic-resistant strains.
Used in Research and Development:
Due to its unique structure and potential biological activities, ETHYL 2-AMINO-4-METHYLPYRIMIDINE-5-CARBOXYLATE is utilized in research and development for the discovery of new compounds with therapeutic and agricultural applications. Its versatility allows scientists to explore its potential in various fields, including drug design, pesticide development, and material science.

InChI:InChI=1/C8H11N3O2/c1-3-13-7(12)6-4-10-8(9)11-5(6)2/h4H,3H2,1-2H3,(H2,9,10,11)

Upstream product

• 7234-25-5 4-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 
• 593-85-1 diguanidine carbonate 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 134653-70-6 ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate 
• 593-87-3 guanidine acetic acid 
• 50-01-1 guanidine hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 188781-08-0 2-chloro-4-methylpyrimidine-5-carboxylic acid ethyl ester 
• 6214-64-8 6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester 
• 17994-55-7 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 947592-75-8 2-amino-4-methyl-pyrimidine-5-carboxylic acid hydrazide 
• 769-51-7 2-amino-4-methylpyrimidine-5-carboxylic acid 
• 1258197-07-7 C₂₄H₃₀ClN₉O₂ 
• 1258197-20-4 C₁₃H₁₃ClN₄O 
• 926304-84-9 2-(4-bromo-phenylamino)-4-methyl-pyrimidine-5-carboxylic acid ethyl ester 
• 108-52-1 4-Methyl-pyrimidin-2-ylamin 

Relevant academic research and scientific papers

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Recyclization reactions of 1-alkylpyrimidinium salts

The reaction of 4-amino-2-benzyl-1-methyl-5-ethoxycarbonylpyrimidinium iodide ( 3 ) with alcoholic methylamine resulted in the formation of the methylimine of 2-amino-4- hydroxy-6-methylamino-5-phenylpyridine-3-carbaldehyde ( 5 ). Heating of the same pyri

Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity

A series of pyrimidine derivatives bearing amine substituents at C-2 position were obtained from Biginelli 3,4-dihydropyrimidin-2(1H)-ones and the effect of structural variation on anti-TB activity against Mycobacterium tuberculosis H37Rv strai

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.

RECYCLIZATION OF 5-CARBETHOXY-4-METHYL-2-MERCAPTO(AMINO, HYDROXY) PYRIMIDINES TO GIVE 5-ACETYL-2-MERCAPTO(AMINO, HYDROXY)-4-HYDROXYPYRIMIDINES

Conditions for the selective preparation of 5-carbethoxy-4-methyl-2-substituted pyrimidines or 5-acetyl-4-hydroxy-2-substituted pyrimidines by condensation of ethoxymethyleneacetoacetic ester with 1,3-binucleophiles are proposed.It is shown that under the influence of sodium ethoxide 5-carbethoxy-4-methyl-2-substituted pyrimidines undergo rearrangement to 5-acetyl-4-hydroxy-2-substituted pyrimidines.