81698-18-2

Upstream product

• 102028-51-3 2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 141-52-6 sodium ethanolate 
• 1663-67-8 malonoyl dichloride 
• 1859-76-3 2-(methylamino)benzophenone 
• 178215-63-9 N-(2-Benzoyl-phenyl)-malonamic acid ethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 

Downstream Products

• 178215-64-0 1-methyl-2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid 
• 1033342-93-6 1-methyl-3,4-diphenylquinolin-2(1H)-one 
• 2584-37-4 1-methyl-4-phenyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

Catalytic asymmetric hydrogenation of 3-ethoxycarbonyl quinolin-2-ones and coumarins

A protocol of iridium catalyzed asymmetric hydrogenation of 4-alkyl substituted 3-ethoxycarbonyl quinolin-2-ones and coumarins has been reported, providing a wide range of chiral dihydroquinolin-2-ones and dihydrocoumarins in high yields with excellent enantioselectivities (up to 99% ee) and high turnover numbers (up to 28 000). This efficient protocol was successfully applied for the synthesis of MPR3160 and the key chiral intermediate of R-106578.

Synthesis of 3,4-disubstituted quinolin-2-(1H)-ones via palladium-catalyzed decarboxylative arylation reactions

The Pd-catalyzed decarboxylative cross-coupling reaction of 4-substituted quinolin-2(1H)-one-3-carboxylic acids with (hetero)aryl halides is described. With palladium(II) bromide and triphenylarsine ligand as the catalyst system, a variety of 4-substituted 3-(hetero)aryl quinolin-2(1 H)-ones and related heterocycles, such as 4-substituted 3-arylcoumarins can be prepared in good to excellent yields. Copyright

Quinolone derivatives: Synthesis and binding evaluation on cholecystokinin receptors

A series of 1,2-dihydro-4-phenylquinolin-2-one-3-carboxylic acid and of 3-amino-4-phenylcarbostyril derivatives were synthesized and examined for their CCK receptor affinities. These compounds displayed micromolar affinities for CCK-A rather than CCK-B receptor and the results have been discussed on the basis of a molecular modelling study.