81699-67-4

Basic information

• Product Name: Benzenepropanoic acid, b-methyl-a-methylene-, ethyl ester
• CAS NO: 81699-67-4
• Molecular Formula: C13H16O2
• Molecular Weight: 204.269
• Mol File: 81699-67-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-methyl-a-methylene-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-methyl-a-methylene-, ethyl ester(81699-67-4)
• EPA Substance Registry System: Benzenepropanoic acid, b-methyl-a-methylene-, ethyl ester(81699-67-4)

Safety Data

• Hazardous Substances Data: 81699-67-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 150881-63-3 2-ethoxycarbonyl-3-phenylbutanoic acid 
• 109-89-7 diethylamine 
• 75-24-1 trimethylaluminum 
• 124778-94-5 ethyl 2-(chloromethyl)-3-phenyl-(Z)-2-propenoate 
• 13507-49-8 2-(diethoxyphosphoryl)-3-phenylacrylic acid ethyl ester 
• 585-71-7 (1-bromoethyl)benzne 
• 81699-64-1 2,2-Dimethyl-3-phenyl-3-(toluene-4-sulfonyloxy)-propionic acid ethyl ester 
• 50-00-0 formaldehyd 
• 93969-90-5 2-(diethoxyphosphoryl)-3-methyl-3-phenyl-propionic acid ethyl ester 

Downstream Products

• 150881-36-0 (S)-2-(2-Acetylsulfanylmethyl-3-phenyl-butyrylamino)-propionic acid benzyl ester 
• 155895-89-9 (S)-2-((2R,3R)-2-Mercaptomethyl-3-phenyl-butyrylamino)-propionic acid 
• 155895-89-9 (S)-2-((2R,3S)-2-Mercaptomethyl-3-phenyl-butyrylamino)-propionic acid 
• 155895-89-9 RB 105 
• 155895-89-9 (S)-2-((2S,3S)-2-Mercaptomethyl-3-phenyl-butyrylamino)-propionic acid 
• 155895-89-9 (S)-2-(2-Mercaptomethyl-3-phenyl-butyrylamino)-propionic acid 
• 150881-70-2 (2R,3R)-2-<(acetylthio)methyl>-3-phenylbutanoic acid 
• 150881-68-8 (2R,3S)-2-<(acetylthio)methyl>-3-phenylbutanoic acid 
• 150881-69-9 (2S,3R)-2-<(acetylthio)methyl>-3-phenylbutanoic acid 
• 155779-75-2 (2S,3S)-2-<(acetylthio)methyl>-3-phenylbutanoic acid 
• 150881-62-2 2-<(acetylthio)methyl>-3-phenylbutanoic acid 

Relevant articles and documents

Mapping the mechanism of nickel-ferrophite catalysed methylation of baylis-hillman-derived SN2′ electrophiles

Enantioselective Ni-catalysed methylation of Baylis-Hillman-derived allylic electrophiles in the presence of ferrophite ligands has been investigated computationally and experimentally. The sense and degree of enantioselectivity attained is independent of both the leaving group and the isomeric structure of the initial allylic halide. DFT studies support the selective formation of a limited number of energetically favoured anti and syn π-allyl intermediates. The observed regio- and enantioselectivity can be rationalised based on the energetics of these structures.

N-[MERCAPTOACYL(AMINO ACID OR PEPTIDE)] COMPOUNDS AND S-LIPOPHILIC ALIPHATIC CARBONYL DERIVATIVES THEREOF AS ANTIHYPERTENSIVES

N-[Mercaptoacyl(amino acid or peptide)] compounds and S-lipophilic aliphatic carbonyl derivatives thereof, and pharmaceutical compositions comprising such compounds, as well as the use of these compounds as antihypertensives by the inhibition of neutral endopeptidase and/or peptidyldipeptidase A are disclosed. Methods for preparing the such compounds and derivatives are disclosed also.

N-(mercaptoacyl)amino acids, methods of their preparation and therapeutic use, and pharmaceutical compositions containing them

The present invention is directed to a compound of the formula (I) wherein, R represents a hydrogen atom or an acyl, aroyl or cycloalkylcarbonyl radical or a residue of formula R1 represents an alkyl radical;, R2 represents an aryl o