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81743-88-6

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81743-88-6 Usage

Chemical Structure

Contains a benzene ring fused to an isoselenazol ring, with a carbonyl group at position 3 and a 4-methylphenyl group at position 2.

Antioxidative Properties

Ebselen has been shown to have antioxidant properties, which can help protect cells from damage caused by reactive oxygen species (ROS).

Anti-Inflammatory Properties

Ebselen has demonstrated anti-inflammatory effects, which can be beneficial in reducing inflammation associated with various diseases and conditions.

Potential Applications

Ebselen has been studied for its potential use in treating a range of diseases and conditions, including cancer, stroke, dementia, and psychiatric disorders.

Neuroprotective Effects

Ebselen has shown neuroprotective effects, which can be useful in protecting the brain and nervous system from damage.

Antiviral Activity

Ebselen has been investigated for its potential antiviral activity, which could be useful in the development of new treatments for viral infections.

Protection Against Oxidative Stress

Ebselen has been studied for its potential use in protecting against oxidative stress, which can contribute to the development of various diseases and conditions.

Inflammation Reduction

Ebselen has been investigated for its potential to reduce inflammation, which can be beneficial in the treatment of various inflammatory diseases.

Research and Development

Ebselen is a promising candidate for further research and development in the fields of medicine and pharmacology due to its various potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 81743-88-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,7,4 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 81743-88:
(7*8)+(6*1)+(5*7)+(4*4)+(3*3)+(2*8)+(1*8)=146
146 % 10 = 6
So 81743-88-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H11NOSe/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3

81743-88-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-methylphenyl)-1,2-benzoselenazol-3-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:81743-88-6 SDS

81743-88-6Relevant articles and documents

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis

Cao, Hongxuan,Chen, Han,Han, Xinya,Huang, Yunyuan,Liu, Jiaqi,Peng, Chao,Rao, Li,Ren, Yanliang,Sheng, Chunquan,Su, Chen,Tu, Jie,Wan, Chen,Wan, Jian,Wen, Wuqiang

, p. 2656 - 2674 (2022/02/09)

Fructose-1,6-bisphosphate aldolase (FBA) represents an attractive new antifungal target. Here, we employed a structure-based optimization strategy to discover a novel covalent binding site (C292 site) and the first-in-class covalent allosteric inhibitors

Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors

Bray, William,Carlin, Aaron F.,Clark, Alex E.,Endsley, Mark,Huante, Matthew B.,Huff, Sarah,Kummetha, Indrasena Reddy,Rana, Tariq M.,Smith, Davey,Tiwari, Shashi Kant,Wang, Shaobo

, (2021/10/20)

The emergence of a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents an urgent public health crisis. Without available targeted therapies, treatment options remain limited for COVID-19 patients. Using medicinal chemistry and rational drug design strategies, we identify a 2-phenyl-1,2-benzoselenazol-3-one class of compounds targeting the SARS-CoV-2 main protease (Mpro). FRET-based screening against recombinant SARS-CoV-2 Mpro identified six compounds that inhibit proteolysis with nanomolar IC50 values. Preincubation dilution experiments and molecular docking determined that the inhibition of SARS-CoV-2 Mpro can occur by either covalent or noncovalent mechanisms, and lead E04 was determined to inhibit Mpro competitively. Lead E24 inhibited viral replication with a nanomolar EC50 value (844 nM) in SARS-CoV-2-infected Vero E6 cells and was further confirmed to impair SARS-CoV-2 replication in human lung epithelial cells and human-induced pluripotent stem cell-derived 3D lung organoids. Altogether, these studies provide a structural framework and mechanism of Mpro inhibition that should facilitate the design of future COVID-19 treatments.

Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties

Pietka-Ottlik, Magdalena,Burda-Grabowska, Ma?gorzata,Wo?na, Marta,Waleńska, Joanna,Kaleta, Rafa?,Zaczyńska, Ewa,Piasecki, Egbert,Giurg, Miros?aw

, p. 546 - 556 (2017/03/14)

A series of new mono and disubstituted alkylated and methoxylated benzisoselanzol-3(2H)-ones and bis(2-carbamoylaryl)diselenides were prepared in yields ranging from 55% to 95% starting from anthranilic acid and were evaluated for antiviral and antimicrobial activity. The compounds exhibited antiviral activity against Human herpes virus 1 and Encephalomyocarditis virus as well as antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Candida albicans. (Chemical Equation Presented).

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