81787-41-9Relevant academic research and scientific papers
Synthesis of (E)-α,β-Unsaturated Carbonyls via Silver-Catalyzed Tandem Epoxide Rearrangement/Intermolecular Carbonyl- Heteroalkyne Metathesis
Zhu, Hui,Jin, Weiwei,He, Jiayao,Zhang, Yan,Zhu, Gangguo
supporting information, p. 3730 - 3735 (2016/12/16)
A regio- and stereoselective method for the synthesis of (E)-α,β-unsaturated carbonyls has been developed via a silver-catalyzed tandem epoxide rearrangement/intermolecular carbonyl-heteroalkyne metathesis. Various heteroalkynes including ynol ethers, ynamides, and thioalkynes work well for this transformation, leading to the production of (E)-α,β-unsaturated esters, amides, and thioesters in moderate to excellent yields with good functional group compatibility. It represents one of the rare examples of regio- and stereoselective intermolecular alkyne-carbonyl metathesis (ACM). (Figure presented.).
A convenient titanium-mediated intermolecular alkyne-carbonate coupling reaction
Wolan, Andrzej,Cadoret, Frédéric,Six, Yvan
experimental part, p. 7429 - 7439 (2009/12/06)
A direct diastereoselective titanium-mediated intermolecular coupling of internal alkynes with dialkyl carbonates under Kulinkovich-type reaction conditions is presented. The influence of the structures of the coupling partners on the yields and regioselectivities of this transformation is described.
