81864-29-1

Upstream product

• 6324-89-6 2,2-dimethylbenzo[d][1,3]dioxol-5-ylamine 
• 108-24-7 acetic anhydride 
• 54186-68-4 2,2-dimethyl-5-nitro-1,3-benzodioxole 
• 7631-86-9 SiO₂ 
• 75200-79-2 2,2-dimethylbenzo[1,3]dioxol-5-amine hydrochloride 
• 75-36-5 acetyl chloride 

Downstream Products

• 37519-14-5 3-Hydroxyacetaminophen 
• 81864-31-5 2,2-dimethyl-6-nitro-benzo[1,3]dioxol-5-ylamine 

Relevant academic research and scientific papers

Practical Cleavage of Acetals by Using an Odorless Thiol Immobilized on Silica

A practical, efficient and general method was developed for the deprotection of a variety of aromatic and aliphatic acetals to their corresponding catechol or diol derivatives using thiol immobilized on silica gel. This is an application for the well-known commercial solid-supported thiol (SiliaMetS Thiol). The procedure is mild and amenable to scale-up. It does not require inert atmosphere and clean conversions were observed. This method is applicable to substituted 1,3-benzodioxole and aliphatic acetals with different functionalities. It offers the advantage of a general route with high yield, which can be undertaken at ambient temperature.

Imidazole derivatives

Tricyclic imidazole derivatives of the formula STR1 wherein R1 is 2-pyridyl optionally substituted by lower alkyl or lower alkoxy, n is the integer 0 or 1, R2 is hydrogen or lower alkyl, R3 and R4, independently, are hydrogen or lower alkyl, A is a group of the formula STR2 m is the integer 2 or 3, R5, R6, R7 and R8, independently, are hydrogen or lower alkyl, and R9 is hydrogen and R10 is hydrogen or lower alkyl or R9 and R10 taken together are oxo, provided that at least one of R3 and R4 is lower alkyl when A is a group of the formula and their pharmaceutically acceptable acid addition salts. The compounds of formula I inhibit gastric acid secretion and prevent the formation of gastric ulcers.