6324-89-6

Usage

Uses

Used in Organic Synthesis:
2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE is used as a reagent in organic synthesis for forming carbon-carbon and carbon-nitrogen bonds, which are fundamental in constructing complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE is utilized as a building block for the production of various pharmaceuticals. Its structural features and amine functional group contribute to its potential in the development of new drugs and medically important compounds.
Used in Agrochemical Development:
Similarly, in agrochemical research, 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE serves as a precursor in the synthesis of agrochemicals, highlighting its versatility across different sectors of chemical compound development.
Used in Medicinal Chemistry:
Due to its potential biological activities stemming from the amine functional group, 2,2-DIMETHYL-BENZO[1,3]DIOXOL-5-YLAMINE holds significance in medicinal chemistry, where it may contribute to the discovery and design of novel therapeutic agents.

InChI:InChI=1/C9H11NO2/c1-9(2)11-7-4-3-6(10)5-8(7)12-9/h3-5H,10H2,1-2H3

Upstream product

• 120-80-9 benzene-1,2-diol 
• 54186-68-4 2,2-dimethyl-5-nitro-1,3-benzodioxole 
• 14005-14-2 2,2-dimethyl-1,3-benzodioxole 

Downstream Products

• 81864-29-1 N-(2,2-dimethylbenzo[1,3]dioxol-5-yl)acetamide 
• 61963-88-0 N²-cyclohexyl-3-nitro-2-aminopyridine 

Relevant academic research and scientific papers

SYNTHESIS AND SOLVATOCHROMIC AND ACID-BASE REACTIONS OF A BETAINE AND SALTS OF 4-N-PYRIDINIUMCATECHOL

Oxidation of catechol by phenyliodosyldiacetate in the presence of pyridine gives 4-N-pyridiniumcatechol salts whose structures are confirmed by an independent synthesis from 2,2-dimethyl-5-aminobenzodioxole.The spectroscopically determined ionization constants for the 4-N-pyridiniumcatechol cation depend on the nature of the buffer cation solution (sodium, ammonium, tetraethylammonium).The large solvatochromic shift in the long wavelength absorption band of the betaine of 4-N-pyridinium-catechol followed the empirical scale of solvent polarity ENT.Introduction of the N-pyridinium group in position 4 increases the acidity of the catechol by 2.7 pK units, which is an almost identical effect to the introduction of a 4-nitro group.However, the solvatochromism for the anion of 4-nitrocatechol is insignificant.The compounds were characterized by their 1H NMR and IR spectra.

An Improved Method for the Synthesis of 2,2-disubstituted and 2-Monosubstituted 1,3-Benzodioxoles

The reactions of catechol with ketones and aldehydes have been studied and convenient procedures have been developed for the preparation of the title compounds in high yields.These products undergo virtually quantitative nitration at position 5, thus providing a source of derivatives substituted in the benzene ring.

Imidazo pyridine-2-ones and pharmaceutical compositions and methods of treatment utilizing same

1,3-Dihydroimidazo[4,5-b]pyridin-2-ones and corresponding thiones have utility as analgesic, antipyretic and antiinflammatory agents. They are generally prepared by treatment of a 2,3-diaminopyridine with phosgene or thiosphosgene followed by further substitution if desired.

3-Phenyl,3H 1,2,3 triazolo[4,5-b]pyridines

3H-1,2,3-Triazolo[4,5-b]pyridines substituted in the 3-position have utility as analgesic, anti-inflammatory and anti-pyretic agents. They are prepared by diazotization of a 3-amino-2-(substitute) aminopyridine.