81928-53-2Relevant academic research and scientific papers
gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity
Nguyen,Niesor,Bentzen
, p. 1426 - 1433 (2007/10/02)
New diphosphonate compounds and related derivatives were synthesized and investigated for their activity in specifically inducing plasma high density lipoproteins (HDL) and high density lipoprotein cholesterol (HDL-C) in normal rats. The screening of nume
Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds
-
, (2008/06/13)
The present invention relates to a pharmaceutical composition for increasing the relative quantity of circulating high density lipoproteins favorable augmentating the alpha/beta lipoprotein cholesterol ratios and clearing cholesterol and lipids from certain tissues and inducing hypotensive activity comprising administering to a human an effective amount of a compound of the formula: STR1 where X is H, OH, or STR2 R and R' identical or different are H, CH3 or C2 H5 ; m is zero or 1; and A is selected from the group comprising (CH3)3 C--, Y--C6 H4 --, Y--C6 H4 --O--C(CH3)2 --, Y--C6 H4 --C(CH3)2 --, Y--C6 H4 --C(O)--C6 H4 --, Y--C6 H4 --(CH2)n -- and Y--C6 H4 --O--(CH2)n --, where n is an integer from 1 to 6 and Y is H, CH3, OCH3, a halogen, and a pharmaceutically acceptable excipient.
