81963-54-4

Upstream product

• 98664-44-9 4,5-dimethoxycarbonyl-1-phenyl-3-trifluoromethylpyrazole 
• 81963-43-1 2,2,2-trifluoromethylphenylhydrazine chloride 
• 624-49-7 dimethylfumarate 
• 100-63-0 phenylhydrazine 
• 81963-44-2 bromure de N-phenyl trifluoroacetohydrazonoyle 
• 86508-64-7 3-phenyl-5-trifluoromethyl-2,2,2-tris(4-methylphenoxy)-2,3-dihydro-1,3,4,2-oxadiazaphosphole 
• 98664-43-8 trans-4,5-dimethoxycarbonyl-1-phenyl-3-trifluoromethyl-2-pyrazoline 
• 81963-42-0 phenylhydrazone of trifluoroacetaldehyde 
• 922-67-8 propynoic acid methyl ester 
• 92387-97-8 methyl 5-amino-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

Synthesis and Reaction of 5-Amino-3-trifluoromethylisoxazole and -pyrazole-4-carboxylic Acids

5-Amino-3-trifluoromethylisoxazole- and -pyrazole-4-carboxylic acids were prepared by the reactions of trifluoroacetonitrile oxide or -imines with cyanoacetic acid derivatives, respectively.The behavior of thus obtained aminoazole-4-carboxylic acids towar

Cycloadditions of N-Aryl-C-(Trifluoromethyl)nitrilimines with Dimethyl Fumarate and Maleate

The cycloadditions of N-aryl-C-(trifluoromethyl)nitrilimines 1, generated in situ from various precursors, with dimethyl fumarate and maleate are described.N-Aryltrifluoroacetohydrazonoyl bromides 2 reacted with fumarate in the presence of triethylamine to give the trans-4,5-dimethoxycarbonylpyrazolines 4 whereas the reactions with maleate afforded the 4,5-dimethoxycarbonylpyrazoles 5 as well as 4.In the reactions with the chloride 6 under the more drastic conditions, both fumarate and maleate gave the pyrazole 5a.From thermolysis of the oxadiazaphosphole 8, thetrans-pyrazoline 4a was formed in both cases of fumarate and maleate.The preparation of the cis-pyrazoline 9 was attempted from 8 and maleic anhydride but 9 was found to be so unstable as to be epimerized under the mild conditions.

PREPARATION OF TRIFLUOROACETONITRILE PHENYLAMINE AND ITS REACTIONS WITH SOME DIPOLAROPHILES

Trifluoroaceto-N-phenylhydrazonoyl halides, the precursors of trifluoroacetonitrile phenylamine, prepared by halogenation of trifluoroacetaldehyde phenylhydrazon, react with various olefins and acetylenes in the presence of triethylamine to give 3-trifluo