819871-13-1

Usage

Chemical Properties

White Solid

Uses

Protected Lisdexamphetamine.

Upstream product

• 51-64-9 dexamfetamine 
• 2483-46-7 Boc-Lys(Boc)-OH 
• 17279-36-6 D-amphetamine sulfate 
• 60-15-1 2-amino-1-phenylpropane 
• 2483-48-9 (+)-(S)-N₂,N₆-bis[(1,1-dimethylethoxy)carbonyl]-lysine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 30189-36-7 N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester 
• 1485-13-8 (-)-(2S,3R)-cis-2-methyl-3-phenylaziridine 

Downstream Products

• 51-64-9 dexamfetamine 
• 914480-48-1 L-lysine-d-amphetamine dihydrochloride 

Relevant academic research and scientific papers

PROCESS FOR PREPARING ACYLATED AMPHETAMINE DERIVATIVES

Processes for preparing acetylated amphetamine derivatives and, in particular, processes for preparing L-lysine-D-amphetamine dimesylate from D-amphetamine salts.

AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE-DETERRENT DOSAGE FORMS

The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

PROCESS FOR PREPARATION OF LISDEXAMPHETAMINE

The present invention relates to a process for preparation of lisdexamphetamine and its pharmaceutically acceptable salts via a novel aziridine intermediate of Formula IV.

AMPHETAMINE CONTROLLED RELEASE, PRODRUG, AND ABUSE DETERRENT DOSAGE FORMS

The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

PROCESS FOR THE PREPARATION OF LISDEXAMFETAMINE AND RELATED DERIVATIVES

The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

PROCESS FOR PREPARATION OF LISDEXAMPHETAMINE AND SALTS THEREOF

An improved, efficient, safe and convenient process for preparation of lisdexamphetamine and its pharmaceutically acceptable salts by using novel mixed anhydride intermediate is provided. A process for preparation of diamino protected amide compound namely BOC protected lisdexamphetamine, a key intermediate in the preparation of lisdexamphetamine and its pharmaceutically acceptable salts by using novel mixed anhydride intermediate and its purification by crystallization are also provided. Further, novel mixed anhydride intermediate is provided too.

PROCESS FOR THE SYNTHESIS OF AMPHETAMINE DERIVATIVES

The invention relates to a process for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be coupled acid or a salt of the to be coupled acid which acid is protected or not protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and - provided the acid (V2) was protected - the cleavage of the protecting group(s), in a one-pot reaction or in two or more separate steps.