82038-67-3

Usage

Uses

Used in Chemical Synthesis:
Pyrrolidine, 1-(1-oxo-2-propynyl)(9CI) is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile reactions and the formation of a wide range of compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Pyrrolidine, 1-(1-oxo-2-propynyl)(9CI) is utilized as a pharmaceutical intermediate. This role is crucial for the synthesis of various drugs, contributing to the development of new medications and therapies.
Used in Specialty Chemicals Production:
Pyrrolidine, 1-(1-oxo-2-propynyl)(9CI) is employed in the production of specialty chemicals, which are high-value compounds used in specific industries such as agriculture, coatings, and materials science.
Used in Research and Development:
Pyrrolidine, 1-(1-oxo-2-propynyl)(9CI) is a subject of ongoing research for its potential medicinal properties. Scientists are exploring its biological activity to discover new applications in medicine and healthcare.

InChI:InChI=1/C7H9NO/c1-2-7(9)8-5-3-4-6-8/h1H,3-6H2

Upstream product

• 123-75-1 pyrrolidine 
• 623-47-2 propynoic acid ethyl ester 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 217461-70-6 4-Methoxy-benzoic acid 4-{[butyl-((E)-3-oxo-3-pyrrolidin-1-yl-propenyl)-amino]-methyl}-3-iodo-benzyl ester 
• 920518-32-7 {cis-4-[4-(pyrrolidine-1-carbonyl)-[1,2,3]triazol-1-yl]-cyclohexyl}-carbamic acid tert-butyl ester 
• 1286783-66-1 (R)-5H-5-benzyloxybutyl-5-[(Z)-3-oxo-3-(pyrrolidin-1-yl)propenyl]-2-phenyloxazol-4-one 
• 1286783-64-9 (R)-5H-5-benzyl-5-[(Z)-3-oxo-3-(pyrrolidin-1-yl)propenyl]-2-phenyloxazol-4-one 
• 1286783-61-6 (R)-5H-5-methyl-5-[(Z)-3-oxo-3-(pyrrolidin-1-yl)propenyl]-2-phenyloxazol-4-one 
• 1286783-63-8 (R)-5H-5-(1-methylethyl)-5-[(Z)-3-oxo-3-(pyrrolidin-1-yl)propenyl]-2-phenyloxazol-4-one 
• 1286783-65-0 (R)-5H-5-allyl-5-[(Z)-3-oxo-3-(pyrrolidin-1-yl)propenyl]-2-phenyloxazol-4-one 
• 1286783-62-7 (R)-5H-5-butyl-5-[(Z)-3-oxo-3-(pyrrolidin-1-yl)propenyl]-2-phenyloxazol-4-one 
• 1485105-61-0 C₂₅H₄₁AuNOP 
• 51459-75-7 1-phenyl-4-(pyrrolidine-1-yl) butane-1,4-dione 

Relevant academic research and scientific papers

Homoleptic gold(i) N-heterocyclic allenylidene complexes: Excited-state properties and lyotropic chromonics

A series of phosphorescent Au(i) bis(N-heterocyclic allenylidene) complexes, namely [Au(=C=C=CR1R2)2]+X-, were synthesized and structurally characterized. These organometallic complexes exhibit panchromatic transient absorption upon electronic photo-excitation and can self-organize into lyotropic chromonic mesophases in aqueous solutions.

Competitive Copper Catalysis in the Condensation of Primary Nitro Compounds with Terminal Alkynes: Synthesis of Isoxazoles

Isoxazoles, mainly 3,5-disubstituted, are prepared by catalytic condensation of primary nitro compounds with terminal acetylenes by using a copper/base catalytic system. The additional catalytic effect of the copper(II) salts is evidenced by comparing the kinetic profiles. Selectivity dependence on reaction conditions is considered for phenylacetylene in the following competitive processes: oxidative coupling of terminal alkynes to conjugated diynes catalyzed by CuIIand base in the presence of air; production of furazans beside condensation with benzoylnitromethane to 3-benzoylisoxazoles, as a result of the reaction of the dipolarophile with 3,4-dibenzoylfuroxan; addition of electron-poor alkynes (e.g., methyl propiolate) with themselves and with the nitro compound. Thus, oxidative coupling is negligible in reactions with “active” nitro compounds, whereas with nitroalkanes both products are observed: only trace amounts of isoxazoles are detected without copper. Similarly, in the presence of copper, 3-benzoyl-5-phenylisoxazole is predominant over the furazan. Furthermore, condensations of electron-poor alkynes give complex reaction mixtures in the presence of base alone, but cycloadducts are conveniently prepared with copper. The results indicate the practical and general utility of this catalytic method for synthetic practice.

FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS

A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Radical and palladium-mediated cyclizations of ortho-iodo benzyl enamines: A scope and limitation study

Radical and palladium-mediated cyclizations of ortho-iodo benzyl enamines were compared to determine their potential application to the synthesis of libraries of compounds on solid support.

A new method for the synthesis of cyclopentenones via the tandem Michael addition-carbene insertion reaction of β-ketoethynyl(phenyl)iodonium salts

A variety of substituted 2-cyclopentenones are obtained in good yields (53-82%) via intramolecular 1,5-carbon-hydrogen insertion reactions of [β- (p-toluenesulfonyl)alkylidene]carbenes derived from Michael addition of sodium p-toluenesulfinate to β-ketoet