82063-02-3

Upstream product

• 3752-97-4 1,4-bis(chloromethyl)-2,5-dimethoxybenzene 
• 114558-97-3 1,1'-(2,5-dimethoxy-p-xylylene)-bis-hexamethylenetetraminium; dichloride 
• 50874-27-6 1,4-bis(bromomethyl)-2,5-dimethoxybenzene 
• 150-78-7 1,4-dimethoxybezene 
• 141-82-2 malonic acid 
• 7310-97-6 2,5-dimethoxyterephthalaldehyde 

Downstream Products

• 40995-85-5 3,3'-(2,5-dimethoxy-p-phenylene)-di-propionic acid 
• 178200-84-5 diethyl 3,3'-(2-methoxy-5-methyl-1,4-phenylene)(2E,2'E)-diacrylate 
• 82997-81-7 diethyl 3,3'-(2,5-dimethoxy-p-phenylene)dipropionate 
• 5628-27-3 3,3'-(2,5-Dimethoxy-1,4-phenylen)di-1-propanol 

Relevant academic research and scientific papers

Novel seco cyclopropa[c]pyrrolo[3,2-e]indole bisalkylators bearing a 3,3′-arylenebisacryloyl group as a linker

We synthesized the novel seco cyclopropa[c]pyrrolo[3,2-e]indole (CPI) bisalkylators and evaluated their antitumor activity. Among these derivatives, 11a (AT-760), in which the two seco 3-methoxycarbonyl-2-trifluoromethyl CPI (MCTFCPI) moieties are connected with a 3,3′-(1,4-phenylene)bisacryloyl group, was found to exhibit more potent cytotoxicity and antitumor activity against HeLaS3 human uterine cervix carcinoma cells and Colon 26 adenocarcinoma cells, respectively, than 8 (bizelesin, U-77,779). It also appeared that compound 11a exhibits improved in vivo efficacy in the human colon CX-1 model when compared to either compound 8 or mitomycin C (MMC). Efficacious doses for 11a were found to be 2-fold lower than those for 8.

Synthesis and Topochemistry of 2,5-Bisacrylate-Substituted 1,4-Benzoquinones

The 2,5-bisacrylate-substituted 1,4-benzoquinone bisketal 7a was synthesized by electrochemical oxidation of the corresponding dimethoxybenzene 6. The methyl ester 7a was transesterified to the corresponding ethyl, n-propyl and isopropyl esters 7b-7d by T

Solid state behaviour of vinyl quinones

2,5-Bisvinyl-1,4-benzoquinones 1 and 2-vinyl-1,4-benzoquinones 2 substituted with aryl or ester end groups have been synthesized. The 2,5-bisstyryl-1,4-benzoquinones 1 (R=phenyl, p-tolyl, o-tolyl) crystallize with a 7 angstrom-stacking axis. But only for the o-tolyl derivative the contacts between the vinyl groups are close enough to allow a four-center type photopolymerization. The ester derivative 1 (R=COOEt) has a layer structure and can be photooligomerized in the crystal. The generated cyclobutane subgroups have twofold symmetry. The vinylquinones 2 (R=aryl) may be dimerized photochemically in the crystal at the vinyl groups to centrosymmetric cyclobutanes. Crystals with 4 angstrom stacking axis are also photoreactive.

Synthesis of Bipyridyl-, Viologen-, and Quinone-bridged Porphyrins

Mesoporphyrin-II has been bridged by several 2,2'-hydroxymethyl-substituted 4,4'-bipyridine compounds.N-Methylation of the bipyridine bridge groups yielded viologen-bridged porphyrins which have unusual aggregation and fluorescence properties.An improved route to quinone-bridged porphyrins is also reported.