82064-07-1

Upstream product

• 98-88-4 benzoyl chloride 
• 27826-73-9 2,5-anhydro-D-glucitol 
• 65729-81-9 2,5-anhydro-1,3-O-isopropylidene-D-glucitol 
• 75499-83-1 2,5-anhydro-4,5-di-O-benzoyl-D-glucitol 
• 98-59-9 p-toluenesulfonyl chloride 
• 75499-82-0 2,5-anhydro-4,5-di-O-benzoyl-1,3-O-isopropylidene-D-glucitol 

Downstream Products

• 243132-01-6 2,5-anhydro-1-azido-4,5-di-O-benzoyl-1-deoxy-D-glucitol 
• 243469-59-2 2,5-anhydro-1-azido-1-deoxy-D-glucitol 

Relevant academic research and scientific papers

Ethambutol-sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis

Ethambutol is an established front-line agent for the treatment of tuberculosis, and is also active against Mycobacterium avium infection. However, this agent exhibits toxicity, and is considered to have low potency. The action of ethambutol on the mycoba

A Stereospecific Synthesis of (+)-Muscarine

A stereospecific synthesis of (+)-muscarine (1) is described in which acid-catalysed cyclisation of D-mannitol gives 2,5-anhydro-D-glucitol, isolated as its 1,3-O-isopropylidene-4,6-dibenzoate (3); acid hydrolysis then tosylation gives the 1,3-di-O-tosyl derivative (7), converted by sodium methoxide-methanol into 2,5:3,4-dianhydro-1-tosyl-D-allitol (8).This epoxide with sodium bis-(2-methoxyethoxy)aluminium hydride gives 2,5-anhydro-1,4-dideoxy-d-ribo-hexitol (10) and its 1,3-dideoxy-isomer (11) (12:1).The former, with tosyl chloride then trimethylamine gives (+)-muscarine tosylate, also isolated as chloride and bromide salts.