82065-23-4

Upstream product

• 627-27-0 homoalylic alcohol 
• 100-52-7 benzaldehyde 
• 2397-79-7 2-phenyl-4H-pyran-4-one 
• 64-17-5 ethanol 
• 546-67-8 lead(IV) tetraacetate 
• 132148-94-8 1-Phenyl-5-tributylstannanyl-pentane-1,3-diol 
• 94426-72-9 2-(2-(benzyloxy)ethyl)oxirane 

Downstream Products

• 147688-62-8 (+/-)-2-phenyl-tetrahydro-2H-pyran-4-one 
• 82110-16-5 (2R,4S)-2-phenyltetrahydro-2H-pyran-4-ol 
• 82110-28-9 (S)-2-phenyl-tetrahydropyran-4-one 
• 82110-27-8 (R)-2-phenyl-tetrahydro-pyran-4-one 
• 1190840-60-8 (2S,4R)-1-[1-(2-phenyl-tetrahydro-pyran-4-yl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one 
• 1190840-52-8 1-[1-(2-phenyl-tetrahydro-pyran-4-yl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one 
• 1359858-75-5 C₁₂H₁₃NO 
• 1359858-76-6 C₁₂H₁₄O₃ 
• 1412450-94-2 C₂₁H₂₄N₂O₃S 

Relevant academic research and scientific papers

Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy

Optimization of lead compound 2 is described, mainly focusing on modification at the C-2 position of the benzimidazole core. Replacement of the phenyl linker of 2 with saturated rings resulted in identification of compound 8b which combines high Y5 recept

Investigation of Prins reaction for the synthesis of 2, 4-disubstituted tetrahydropyran derivatives and 1, 3-dioxanes using polyaniline supported acid as reusable catalyst

The Prins cyclization of homoallyl alcohol with a variety of aldehydes were observed under reflux condition in dichloromethane using both polyaniline supported TsOH (PANI-TsOH) and FeCl3 (PANI- FeCl3) as reusable acid catalysts with the formation of 2,4-disubstituted tetrahydropyran ether as single product. In case of 4-, 3- and 2- nitro benzaldehydes, the reaction generated acetal of the aldehyde and homoallylic alcohol as single product. Additionally, both catalysts were investigated for the synthesis of 1, 3-dioxane in dichloromethane under reflux and at ambient temperature Indian Academy of Sciences.

NOVEL PIPERIDINYL-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AS M1 AGONISTS

The present invention relates to novel M1 agonistic compounds of the present invention and their use in the treatment of cognitive impairment associated i.a. with schizophrenia and in the treatment of other diseases mediated by the muscarinic M1 receptor.

New Oxetane and Tetrahydropyran Synthesis

The base catalysed rearrangement of the benzyl ethers of oxiranylcarbinols and their homologues provides convenient routes to oxetan-3-ylcarbinols and tetrahydropyran-4-ols.

Enzymes in Organic Synthesis. 25. Heterocyclic Ketones as Substrates of Horse Liver Alcohol Dehydrogenase. Highly Stereoselective Reductions of 2-Substituted Tetrahydropyran-4-ones

Horse liver alcohol dehydrogenase (HLADH) has been found to be an efficient catalyst for the reduction of O-heterocyclic ketones.Preparative-scale HLADH-catalyzed reductions of 2-substituted tetrahydropyran-4-ones are enantioselective, with reduction of e