821-91-0

Basic information

• Product Name: 3-(dodecylamino)propane-1,2-diol
• Synonyms: 3-(dodecylamino)propane-1,2-diol;3-(Dodecylamino)-1,2-propanediol;3-Dodecylamino-1,2-propanediol;1,2-Propanediol, 3-(dodecylamino)-;Einecs 212-482-1;N-(2,3-Dihydroxypropyl)dodecylamine
• CAS NO: 821-91-0
• Molecular Formula: C₁₅H₃₃NO₂
• Molecular Weight: 259.42802
• EINECS: 212-482-1
• Mol File: 821-91-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 76.0-76.5 °C
• Boiling Point: 396.6°Cat760mmHg
• Flash Point: 83.3°C
• Appearance: /
• Density: 0.925g/cm³
• Vapor Pressure: 6.19E-08mmHg at 25°C
• Refractive Index: 1.469
• PKA: 14.06±0.20(Predicted)
• CAS DataBase Reference: 3-(dodecylamino)propane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(dodecylamino)propane-1,2-diol(821-91-0)
• EPA Substance Registry System: 3-(dodecylamino)propane-1,2-diol(821-91-0)

Safety Data

• Hazardous Substances Data: 821-91-0(Hazardous Substances Data)

Usage

General Description

3-(dodecylamino)propane-1,2-diol is a chemical compound that belongs to the class of alkanolamines. It is composed of a dodecylamine group attached to the nitrogen atom of a propane-1,2-diol molecule. 3-(dodecylamino)propane-1,2-diol has a long hydrocarbon tail (dodecyl) and a hydroxyl group, making it amphiphilic in nature. It is commonly used as a surfactant and emulsifier in various cosmetic and personal care products, including shampoos, conditioners, and body washes. Its ability to lower the surface tension of liquids and promote the dispersion of immiscible substances makes it a useful ingredient in the formulation of these products. Additionally, it can also be used as a corrosion inhibitor and a component in pharmaceutical formulations.

InChI:InChI=1/C15H33NO2/c1-2-3-4-5-6-7-8-9-10-11-12-16-13-15(18)14-17/h15-18H,2-14H2,1H3

Upstream product

• 124-22-1 n-Dodecylamine 
• 556-52-5 oxiranyl-methanol 
• 616-30-8 3-Amino-1,2-propanediol 
• 143-15-7 1-dodecylbromide 

Relevant articles and documents

Spontaneous membrane fusion induced by chemical formation of ceramides in a lipid bilayer

Mere chemical generation of ceramide and related double-chain lipids in the membrane of small unilamellar vesicles (SUVs) induces fusion of the vesicles. The lipids can be successfully prepared by dehydrocondensation between single-chain lipids (fatty acids and sphingosine or its analogues) in a lipid bilayer of the SUV by using a combination of 2-chloro-4,6-dimethoxy-1,3,5-triazine and amphiphilic tertiary amine catalysts, a process that can be compared to a successive enzyme model system for a fatty acyl-CoA synthetase followed by acyltransferase. The SUV spontaneously undergoes membrane fusion upon this internal chemical stimulation by the artificial enzyme system. Copyright

MOLECULAR AGGREGATE CAPABLE OF UNDERGOING PHASE TRANSITION BY DEHYDRATING CONDENSATION AND METHOD OF PHASE TRANSITION THEREOF

The present invention provides a bilayer membrane vesicle capable of undergoing a phase transition, and the bilayer membrane vesicle comprises as components of the membrane, (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an amine compound having an aliphatic chain of 6 to 20 carbon atoms; and (c) an artificial synthetic lipid or a phospholipid capable of forming a bilayer membrane. Preferably, this bilayer membrane vesicle further comprises (d) a tertiary amine as a component of the membrane. The present invention also provides a method of inducing a phase transition of a bilayer membrane vesicle, the method comprising a step of adding a dehydrating condensing agent or a dehydrating condensing agent precursor having property of accumulating at an interface to the bilayer membrane vesicle. According to the present invention, by causing the lipids that form a molecular aggregate to chemically change, it is possible to change the physical property and the morphology of the molecular aggregate and control the timing of phase transitions such as membrane fusion. In the membrane fusion, for example, fusion can occur without leaking out the contents of the bilayer membrane vesicle.

Compositions for topical application to skin, hair and nails

Compositions for treating skin, hair and nails which contain 25-hydroxycalciferol in combination with a lipid ingredient. The compositions avoid the toxic effects of 1,25-dihydroxycalciferol, yet attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle 25-hydroxycalciferol and a lipid ingredient.