82117-19-9Relevant academic research and scientific papers
The synthesis of ω-(2-aryl-1,3-dioxolan-2-yl)alkyl purine derivatives and their activity towards HIV reverse transcriptase
Komissarov,Valuev-Elliston,Ivanova,Kochetkov,Kritzyn
, p. 37 - 45 (2015/02/05)
Novel derivatives of 6-substituted purines were synthesized by alkylation of 6-substituted purines with various 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. Their inhibitory properties toward HIV reverse transcriptase were studied. The structure-activity relationship within the synthesized compounds was found.
Synthesis of 1-aryl-4-azolylbutanones
Karachev,Popkov
, p. 987 - 993 (2007/10/03)
A convenient method was developed for the synthesis of substituted 4-azolyl-1-arylbutanones from the available γ-chlorobutyrophenones by successive stages of transformation into ketals, alkylation of sodium imidazolate or 1,2,4-triazolate by the ketals in
NPY antagonists: spiroisoquinolinone derivatives
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Page column 11, (2008/06/13)
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of spiroisoquinolinone derivatives of Formula I. As antagonists of NPY-induced feeding behavior, these compounds and known analogs are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
5-HT7 receptor antagonists
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, (2008/06/13)
The present invention relates to compounds having pharmacological activity toward the 5-HT7receptor. Pharmaceutical compositions and methods for their use in the treatment of CNS disorders are described.
