82169-96-8

Basic information

• Product Name: diethyl 3-(4′-methoxyphenyl)isoxazole-4,5-dicarboxylate
• Synonyms: diethyl 3-(4′-methoxyphenyl)isoxazole-4,5-dicarboxylate
• CAS NO: 82169-96-8
• Molecular Weight: 319.314
• Mol File: 82169-96-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: diethyl 3-(4′-methoxyphenyl)isoxazole-4,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 3-(4′-methoxyphenyl)isoxazole-4,5-dicarboxylate(82169-96-8)
• EPA Substance Registry System: diethyl 3-(4′-methoxyphenyl)isoxazole-4,5-dicarboxylate(82169-96-8)

Safety Data

• Hazardous Substances Data: 82169-96-8(Hazardous Substances Data)

Upstream product

• 3717-21-3 p-methoxyl benzaldoxime 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 824-94-2 p-methoxybenzyl chloride 
• 26218-40-6 3,4-bis(4-methoxyphenyl)-1,2,5-oxadiazole-2-oxide 

Downstream Products

• 82164-07-6 3-(4-Methoxy-phenyl)-isoxazole-4,5-dicarboxylic acid bis-benzylamide 
• 874-90-8 4-methoxybenzonitrile 

Relevant articles and documents

Facile One-Pot Transformation of Primary Alcohols into 3-Aryl- and 3-Alkyl-isoxazoles and -pyrazoles

Various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylisoxazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, NH 2 OH, and then NCS, followed by reaction with alkynes in the presence of Et 3 N. Similarly, various primary alcohols were smoothly transformed into 3-aryl- and 3-alkylpyrazoles in good yields in one pot by successive treatment with PhI(OAc) 2 in the presence of TEMPO, PhNHNH 2, and then NCS and decyl methyl sulfide, followed by reaction with alkynes in the presence of Et 3 N. Thus, both 3-aryl- and 3-alkylisoxazoles, and 3-aryl- and 3-alkylpyrazoles could be prepared from readily available primary alcohols in one pot under transition-metal-free conditions.

Zur Reaktion von 1,2,5-Oxadiazol-N-oxiden mit Acetylen-dicarbonsaeurediethylester

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