82231-56-9

Upstream product

• 536-74-3 phenylacetylene 
• 1011-84-3 4-nitrobenzohydroximoyl chloride 
• 5281-18-5 benzaldehyde, hydrazone 
• 99-92-3 p-aminobenzophenone 
• 881214-06-8 1,1-dimethylethyl (4-((1Z)-1-hydroxy-3-oxo-3-phenyl-3-phenylprop-1-en-1-yl)-phenyl)-carbamate 
• 100-52-7 benzaldehyde 
• 2403-30-7 4'-aminochalcone 
• 42558-04-3 4-(5-Phenyl-4,5-dihydro-1H-pyrazol-3-yl)-phenylamine 
• 63532-66-1 3-(4-nitrophenyl)-5-phenyl-1H-pyrazole 

Relevant academic research and scientific papers

Discovery of 5-aryl-3-thiophen-2-yl-1H-pyrazoles as a new class of Hsp90 inhibitors in hepatocellular carcinoma

Although hepatocellular carcinoma (HCC)-related mortality has increased over the past decades, treatment options are still very limited, underlining the need for developing new therapeutic strategies. The molecular chaperone heat shock protein 90 (Hsp90)

Copper on iron promoted one-pot synthesis of β-aminoenones and 3,5-disubstituted pyrazoles

The reaction of hydroximoyl chlorides with acetylenes in the presence of a copper on iron bimetallic system leads to β-aminoenones via reductive ring opening of isoxazole intermediates. The valuable β-aminoenone building blocks can be isolated or transformed into pyrazoles with the addition of hydrazine in a straightforward one-pot procedure.

PYRAZOLE KINASE MODULATORS AND METHODS OF USE

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferationm, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/0r modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.