82243-06-9Relevant academic research and scientific papers
An efficient one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazoles from aldehydes and hydrazides using Lawesson’s reagent
Ko, Inseok,Park, Soojin,Lee, Goeun,Kim, Hakwon
, p. 67 - 78 (2019/03/07)
Five-membered heterocyclic-ring systems, such as thiadiazoles, remain an important and prevalent scaffold in the development of novel leads in medicinal chemistry for a variety of therapeutic targets. A two-step, one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from aryl hydrazides and aryl aldehydes using Lawesson’s reagent is described, yielding 2,5-disubstituted-1,3,4-thiadiazoles in moderate-to-high yields. Based on preliminary biological experiments, some of the newly synthesized thiadiazoles show antioxidant activity.
Thiadiazoles and Dihydrothiadiazoles. Part 5. Synthesis of 2,3-Dihydro-1,3,4-thiadiazoles by Reaction of Aldehydes or Ketones with Thioaroylhydrazines
Evans, D. Michael,Hill, Lawrence,Taylor, David R.,Myers, Malcolm
, p. 1499 - 1506 (2007/10/02)
A general method for the synthesis of 2,5- and 2,2,5-substituted 2,3-dihydro-1,3,4-thiadiazoles is described, involving the condensation of aldehydes or ketones with thioaroylhydrazines.Evidence for the cyclic nature of the products is discussed.The react
2-PHENYL-1,3,4-THIADIAZOL-2-INES
Zelenin, K. N.,Khrustalev, V. A.,Alekseev, V. V.,Sharbatyan, P. A.,Lebedev, A. T.
, p. 683 - 689 (2007/10/02)
According to data from the 1H and 13C NMR spectra in nonpolar media and the mass spectra, alkylidene derivatives of thiobenzhydrazide have a 1,3,4-thiadiazol-2-ine structure rather than a thiobenzhydrazone structure.The products of condensation of thioben
