82244-23-3

Upstream product

• 100-58-3 phenylmagnesium bromide 
• 1121-60-4 pyridine-2-carbaldehyde 
• 31796-72-2 phenyl(2-pyridinyl)methanol 
• 91-02-1 phenyl(pyridin-2-yl)methanone 
• 860449-22-5 (E/Z)-ethyl 3-phenyl-3-(pyridin-2-yl)prop-2-enoate 
• 77744-14-0 1-Phenyl-1-(2-pyridyl)-2-propen-1-ol 

Downstream Products

• 82244-32-4 3-Morpholin-4-yl-1-phenyl-indolizine 
• 82244-33-5 1-Phenyl-3-piperidin-1-yl-indolizine 
• 82244-34-6 Diethyl-(1-phenyl-indolizin-3-yl)-amine 
• 82244-40-4 3-phenyl-3-(2-pyridyl)-2-propenal 

Relevant academic research and scientific papers

SUBSTITUTED HETEROCYCLIC DERIVATIVES AS GPR AGONISTS AND USES THEREOF

The present invention generally relates to substituted heterocyclic derivatives (the compounds of Formula (I)), processes for their preparation, pharmaceutical compositions containing said compounds, their use as G-protein coupled receptor (GPR) agonists, particularly as GPR40 agonists and methods of using these compounds in the treatment of GPR40 mediated diseases or conditions such as Type 2 diabetes, obesity, dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

Synthesis of 3-(Dialkylamino)indolizines. Reaction of 3-(2-Pyridyl)-2-propenals with Secondary Amines

Reaction of 2- or 3-substituted 3-(2-pyridyl)-propenals (3a-f) with secondary amines afforded 2- or 1-substituted 3-(dialkylamino)indolizines (2a-l) in the presence of metal halides.It was found that titanium tetrachloride was the best catalyst.