82447-97-0

Upstream product

• 512-56-1 trimethyl phosphite 
• 123043-99-2 5-ethoxycarbonyl-6-methyl-3-acetyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 123044-27-9 ethyl 1,6-dimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Synthesis and Reactions of "Biginelli-Compounds". Part I

Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.

Oxidation of some derivatives of tetrahydropyrimidine-5-carboxylic acid with selenium dioxide

The oxidation of derivatives of 2-oxo-4-phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid with selenium dioxide was studied. It was observed that the 6-methyl group is oxidized to a hydroxymethyl, formyl, or carboxy group (in the latter case