123043-99-2Relevant academic research and scientific papers
High-throughput synthesis of N3-acylated dihydropyrimidines combining microwave-assisted synthesis and scavenging techniques
Dallinger, Doris,Gorobets, Nikolay Yu.,Kappe, C. Oliver
, p. 1205 - 1208 (2003)
(Matrix presented) The solution-phase synthesis of N3-acylated dihydropyrimidines was achieved utilizing microwave flash heating both in the synthesis (acylation) and purification (scavenging) steps. Quenching times for excess anhydrides using polystyrene
Synthesis of Acetylated Dihydropyrimidine Analogues under Solvent Free Conditions and their Evaluation as Calcium Channel Blockers
Sati, Bhawana,Sati, Hemlata,Saklani, Sarla,Nargund, L. V. G.,Lamma, E. L.,Khaidem, Somila,Bhatt, Prakash Chandra
, p. 1055 - 1059,5 (2020/08/24)
One pot condensation of ethylacetoacetate with various para and ortho substituted aldehydes and urea or thiourea by SnCI2.2H20 affords eight different substituted 3,4-dihydropyrimidine ones/ thiones. Further we prepared acetylated 3,
N1,N3-Diacyl-3,4-dihydropyrimidin-2(1H)-ones: neutral acyl group transfer reagents
Singh, Kamaljit,Singh, Kawaljit
experimental part, p. 10395 - 10399 (2010/02/28)
Readily available N1,N3-diacyl-3,4-dihydropyrimidin-2(1H)-ones efficiently acylate ammonia, primary and secondary amines to furnish primary, secondary and tertiary amides in good to excellent yields. The wide applicability of the procedure is demonstrated
A mild and practical method for the regioselective synthesis of N-acylated 3,4-dihydropyrimidin-2-ones. New acyl transfer reagents
Singh, Kamaljit,Singh, Sukhdeep
, p. 8143 - 8146 (2007/10/03)
The treatment of 3,4-dihydropyrimidin-2-ones with n-BuLi at -78 °C, followed by quenching with various electrophiles furnished N3-substituted derivatives, regioselectively. Further, N1,N3-diacyl derivatives were found to transfer N1-acyl groups to nucleop
Synthesis and Reactions of "Biginelli-Compounds". Part I
Kappe, Christian Oliver,Roschger, Peter
, p. 55 - 64 (2007/10/02)
Various reactions of 2-oxo (or thioxo)-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid derivatives (Biginelli-compounds) were investigated.The site of methylation and acylation on 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester 1a and its 2-oxo derivative 9a was studied.The synthesis of pyrimidothiazines and thiazolopyrimidines was accomplished by condensation of 1a with 1,3- and 1,2-dielectrophiles.A Dimroth-like rearrangement yielding 6H-1,3-thiazines can be observed when 1a was treated with dimethylformamide and phosphorus oxychloride.The formation of indenopyrimidines can be achieved by intramolecular Friedl-Crafts acylation of 9a and 13, respectively.Finally a route for the preparation of 4,6-disubstituted-pyrimidine-5-carbonitriles is presented, starting with Biginelli-compound 25.
