82477-60-9Relevant academic research and scientific papers
Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors
Alen, Jo,Schade, Markus,Wagener, Markus,Christian, Frank,Nordhoff, Sonja,Merla, Beatrix,Dunkern, Torsten R.,Bahrenberg, Gregor,Ratcliffe, Paul
supporting information, p. 6391 - 6397 (2019/07/08)
Genome-wide-association studies in chronic low back pain patients identified sepiapterin reductase as a high interest target for developing new analgesics. Here we used 19F NMR fragment screening for the discovery of novel, ligand-efficient SPR
The first total synthesis and structural determination of TMC-264
Tatsuta, Kuniaki,Furuyama, Akiho,Yano, Tomoe,Suzuki, Yasuaki,Ogura, Takashi,Hosokawa, Seijiro
, p. 4036 - 4039 (2008/09/20)
The first total synthesis and structural determination of TMC-264 has been accomplished. Regioselective bromination, regioselective methoxymethylation, and nickel(0)-Lewis acid-mediated cyclization afforded multi-functionalized 1-methyl-dibenzo[b,d]-pyran
Reaction of Some 1,4-Benzoquinone Mono-oximes with Methanolic Hydrogen Chloride
Sargent, Melvyn V.
, p. 1095 - 1098 (2007/10/02)
When 2-methyl-1,4-benzoquinone 4-oxime (1) reacted with methanolic hydrogen chloride at 25-30 deg C the product was 2-chloro-4,6-dimethoxy-3-methylaniline (2).Similarly 1,4-benzoquinone 4-oxime (7) gave 2-chloro-4,6-dimethoxyaniline (8), 3-methyl-1,4-benzoquinone 4-oxime (11) gave 2-chloro-4-methoxy-6-methoxymethylaniline (12) and 2-chloro-4-methoxy-6-methylaniline (13), and 2-methoxy-1,4-benzoquinone 4-oxime (19) gave 2-chloro-4,5-dimethoxyaniline (20).
