82485-84-5

Upstream product

• 67-56-1 methanol 
• 637-62-7 p-benzoquinone oxime 
• 108-95-2 phenol 
• 104-91-6 p-nitrosophenol 

Downstream Products

• 99848-45-0 1-chloro-2-iodo-3,5-dimethoxybenzene 
• 197799-16-9 N-(2-chloro-4,6-dimethoxyphenyl)-1-(1-ethylpropyl)-6-methyl-1H-1,2,3-triazolo[4,5-c] pyridin-4-amine 
• 138849-53-3 4-chloro-3-pivaloylamino-2,6-dimethoxybenzoic acid 
• 138849-52-2 6-chloro-5-pivaloylamino-2,4-dimethoxybenzaldehyde 
• 138849-54-4 4-chloro-3-pivaloylamino-2,6-dimethoxybenzaldehyde 
• 138849-51-1 6-chloro-5-acetylamino-2,4-dimethoxybenzaldehyde 
• 82477-60-9 2-chloro-4,6-dimethoxybenzoic acid 
• 82477-61-0 2-chloro-4,6-dimethoxybenzaldehyde 
• 1026556-86-4 N-(2-chloro-4,6-dimethoxy-phenyl)-N'-(2-methoxy-ethyl)-N'-(3-methoxy-propyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine 
• 1026799-59-6 N-(2-chloro-4,6-dimethoxy-phenyl)-N''-(2-methoxy-ethyl)-N''-(3-methoxy-propyl)-2-methyl-pyrimidine-4,5,6-triamine 
• 1026901-24-5 N-butyl-N'-(2-chloro-4,6-dimethoxy-phenyl)-N-ethyl-2-methyl-5-nitro-pyrimidine-4,6-diamine 

Relevant academic research and scientific papers

Synthesis of sterically hindered polychlorinated biphenyl derivatives

A series of sterically hindered (methoxylated) polychlorinated biphenyl derivatives were synthesized using the Suzuki and the Ullmann coupling reactions. The Suzuki coupling with Pd(dba)2-dicyclohexylphosphino-2,6- dimethoxybiphenyl (DPDB) gave better yields (65-98%) compared to the classic Ullmann coupling reaction (20-38%). Despite the reactive catalyst system, no significant coupling with aromatic chlorine substituents was observed. Crystal structure analysis of four PCB derivatives revealed solid state dihedral angles ranging from 69.7 to 81.0, which indicates that these highly ortho-substituted PCB derivatives have some conformational flexibility. Georg Thieme Verlag Stuttgart.

Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac

In humans, metabolism of the commonly used nonsteroidal antiinflammatory drug diclofenac 1 yields principally the 4′-hydroxy 2, 5-hydroxy 3, and acyl glucuronide 4 metabolites. All three metabolites have been implicated in rare idiosyncratic adverse react

Reaction of Some 1,4-Benzoquinone Mono-oximes with Methanolic Hydrogen Chloride

When 2-methyl-1,4-benzoquinone 4-oxime (1) reacted with methanolic hydrogen chloride at 25-30 deg C the product was 2-chloro-4,6-dimethoxy-3-methylaniline (2).Similarly 1,4-benzoquinone 4-oxime (7) gave 2-chloro-4,6-dimethoxyaniline (8), 3-methyl-1,4-benzoquinone 4-oxime (11) gave 2-chloro-4-methoxy-6-methoxymethylaniline (12) and 2-chloro-4-methoxy-6-methylaniline (13), and 2-methoxy-1,4-benzoquinone 4-oxime (19) gave 2-chloro-4,5-dimethoxyaniline (20).