82543-06-4

Basic information

• Product Name: N-(4-phenylbutylidene)hydroxylamine
• Synonyms: N-(4-phenylbutylidene)hydroxylamine
• CAS NO: 82543-06-4
• Molecular Weight: 163.219
• Mol File: 82543-06-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(4-phenylbutylidene)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-phenylbutylidene)hydroxylamine(82543-06-4)
• EPA Substance Registry System: N-(4-phenylbutylidene)hydroxylamine(82543-06-4)

Safety Data

• Hazardous Substances Data: 82543-06-4(Hazardous Substances Data)

Upstream product

• 18328-11-5 3-benzyl propionaldehyde 
• 78579-86-9 1-nitro-4-phenylbutane 
• 80922-14-1 1-nitro-4-phenylbut-1-ene 
• 1821-12-1 4-Phenylbutyric acid 
• 3360-41-6 4-phenyl-butan-1-ol 
• 67-56-1 methanol 

Downstream Products

• 82543-04-2 N-Hydroxy-N-(4-phenyl-butyl)-acetamide 
• 253270-24-5 5-phenethyl-3-(3-phenylpropyl)-4,5-dihydroisoxazole 
• 1036384-51-6 5-benzyl-3-(3-phenyl-propyl)-4,5-dihydro-isoxazole 
• 253270-23-4 5-phenyl-3-(3-phenyl-propyl)-4,5-dihydro-isoxazole 
• 2046-18-6 4-phenylbutyronitrile 
• 1311406-36-6 C₂₀H₂₃NO₂ 

Relevant articles and documents

Metal-Free Deoxygenation of Chiral Nitroalkanes: An Easy Entry to α-Substituted Enantiomerically Enriched Nitriles

A metal-free, mild and chemodivergent transformation involving nitroalkanes has been developed. Under optimized reaction conditions, in the presence of trichlorosilane and a tertiary amine, aliphatic nitroalkanes were selectively converted into amines or nitriles. Furthermore, when chiral β-substituted nitro compounds were reacted, the stereochemical integrity of the stereocenter was maintained and α-functionalized nitriles were obtained with no loss of enantiomeric excess. The methodology was successfully applied to the synthesis of chiral β-cyano esters, α-aryl alkylnitriles, and TBS-protected cyanohydrins, including direct precursors of four active pharmaceutical ingredients (ibuprofen, tembamide, aegeline and denopamine).

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2

A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.

Amidyl Radical Directed Remote Allylation of Unactivated sp3 C?H Bonds by Organic Photoredox Catalysis

The development of visible-light-mediated allylation of unactivated sp3 C?H bonds is reported. The remote allylation was directed by the amidyl radical, which was generated by photocatalytic fragmentation of a pre-functionalized amide precursor. Both aromatic and aliphatic amide derivatives could successfully deliver the remote C?H allylation products in good yields. A variety of electron deficient allyl sulfone systems could be used as δ-carbon radical acceptor.