82547-03-3Relevant articles and documents
Glycyrrhetinic acid type derivative as well as preparation method and application thereof
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Paragraph 0042-0048; 0059-0062, (2019/12/25)
The invention relates to a glycyrrhetinic acid type derivative as well as a preparation method and application thereof and belongs to the technical field of organic synthesis. The novel glycyrrhetinicacid type derivative has a molecular formula shown in t
Regioselective iodination of flavonoids by N-iodosuccinimide under neutral conditions
Lu, Kui,Chu, Jie,Wang, Haomeng,Fu, Xiaoli,Quan, Dewu,Ding, Hongxia,Yao, Qingwei,Yu, Peng
supporting information, p. 6345 - 6348 (2013/11/06)
Regioselective synthesis of C-6 and C-8 monoiodo flavonoids, which are important intermediates for the synthesis of flavonoid natural products and drug molecules, was achieved by iodination of suitably alkylated flavonoids with N-iodosuccinimide (NIS) in DMF. The iodination gives either a C-6 or C-8 iodo flavonoid in high yield, depending on the protection pattern of the C-5 and C-7 OH groups. The mild and neutral conditions render this novel protocol particularly useful for the regioselective iodination of acid-sensitive substrates.