82547-03-3

Upstream product

• 117-39-5 quercetol 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 

Downstream Products

• 28334-98-7 Phloroglucinmonoethylether 
• 82547-08-8 [2-(3,4-Diethoxy-phenyl)-3,7-diethoxy-4-oxo-4H-chromen-5-yloxy]-acetic acid ethyl ester 
• 82547-06-6 5-<(diethylamino)ethyl>-3,3',4',7-tetra-O-ethylquercetin hydrochloride 
• 82547-07-7 2-(3,4-diethoxyphenyl)-3,5,7-triethoxy-4H-chromen-4-one 

Relevant academic research and scientific papers

Glycyrrhetinic acid type derivative as well as preparation method and application thereof

The invention relates to a glycyrrhetinic acid type derivative as well as a preparation method and application thereof and belongs to the technical field of organic synthesis. The novel glycyrrhetinicacid type derivative has a molecular formula shown in t

Synthesis of 6- or 8-bromo flavonoids by regioselective mono-bromination and deprotection protocol from flavonoid alkyl ethers

C-6 and C-8 monobromo flavonoids are important building blocks for the synthesis of flavonoid natural products and their derivatives. Bromination of suitably alkylated flavonoids with N-bromosuccinimide in dichloromethane (DCM), followed by deprotection with BCl3, gives either a C-6 or a C-8 monobromo flavonoid in high yield and with high regioselectivity, depending on the protection pattern of the C-5 and C-7 OH groups. The mild and neutral conditions are particularly useful for the regioselective bromination of acid-labile substrates.

Regioselective iodination of flavonoids by N-iodosuccinimide under neutral conditions

Regioselective synthesis of C-6 and C-8 monoiodo flavonoids, which are important intermediates for the synthesis of flavonoid natural products and drug molecules, was achieved by iodination of suitably alkylated flavonoids with N-iodosuccinimide (NIS) in DMF. The iodination gives either a C-6 or C-8 iodo flavonoid in high yield, depending on the protection pattern of the C-5 and C-7 OH groups. The mild and neutral conditions render this novel protocol particularly useful for the regioselective iodination of acid-sensitive substrates.

Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain

Some penta-O-substituted analogues of quercetin were synthesized and tested for the inhibition of cytosolic and particulate rat brain cyclic AMP and cyclic GMP phosphodiesterase activities. Ten of these compounds are potent and highly selective inhibitors of cAMP hydrolysis with respect to cGMP hydrolysis. They inhibit more potently the particulate enzyme than the cytosolic preparation. The highest selectivity was observed with penta-O-ethylquercetin and analogue 6d, which proved to be more selective and more potent inhibitors than the reference compound Ro 20-1724. Some structure-activity relationships are discussed.