193979-48-5

Basic information

• Product Name: ethyl 2-(6-chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)acetate
• Synonyms: ethyl 2-(6-chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)acetate
• CAS NO: 193979-48-5
• Molecular Formula: C₁₇H₁₄Cl₂N₂O₂
• Molecular Weight: 349.21126
• Mol File: 193979-48-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 4.33±0.50(Predicted)
• CAS DataBase Reference: ethyl 2-(6-chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(6-chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)acetate(193979-48-5)
• EPA Substance Registry System: ethyl 2-(6-chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)acetate(193979-48-5)

Safety Data

• Hazardous Substances Data: 193979-48-5(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 1072-98-6 5-chloro-2-pyridylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 623-47-2 propynoic acid ethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 88964-99-2 6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 64-17-5 ethanol 
• 82626-72-0 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetonitrile 
• 89781-40-8 C₁₂H₁₁ClO₃ 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 1381932-40-6 C₁₄H₁₄ClNO₆ 
• 329937-06-6 C₁₂H₈Cl₂N₂ 
• 53503-49-4 ethyl 4-(4-chlorophenyl)-4-oxobutanoate 

Downstream Products

• 82625-99-8 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylacetamide 
• 82626-74-2 2-(6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid 

Relevant articles and documents

Rhodium(II)-Catalyzed Regioselective C3-Alkylation of 2-Arylimidazo[1,2-a]pyridines with Aryl Diazoesters

A regioselective C3-alkylation based on the reaction of 2-arylimidazo[1,2-a]pyridines with a wide range of aryl α-diazoesters in the presence of a Rh(II) catalyst in dichloroethane at room temperature was developed. This method could be applied in the synthesis of benzoimidazoquinolizinone and cycloheptaimidazopyridinone, which are novel heterocyclic scaffolds. (Figure presented.).

3-ALKYLATED IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AND ITS PREPARATION METHOD

Of a typic a.a typa/aβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbeta.beteq.a a.sub .beteq.a.sub βbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβbetaβ

Visible-Light-Induced Regioselective Cyanomethylation of Imidazopyridines and Its Application in Drug Synthesis

3-Cyanomethylated imidazopyridines were synthesized via a visible light-promoted reaction of imidazopyridines with bromoacetonitrile or iodoacetonitrile catalyzed by fac-Ir(ppy)3 under mild conditions. For the substrates with various substituents on benzene or pyridine ring, the reaction proceeded smoothly to give the corresponding products in moderate to good yields. The synthetic utility of this visible-light-induced reaction has been illustrated in the efficient synthesis of zolpidem and alpidem.