82645-11-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(TRIMETHYLSILYL)-1H-INDOLE 98 is used as a building block for the synthesis of pharmaceuticals, as it provides stability and protection to the indole ring during chemical reactions, enabling the development of new and effective drug candidates.
Used in Agrochemical Industry:
4-(TRIMETHYLSILYL)-1H-INDOLE 98 is used as a building block for the synthesis of agrochemicals, contributing to the development of innovative and efficient crop protection agents.
Used in Research Applications:
4-(TRIMETHYLSILYL)-1H-INDOLE 98 is used as a research compound for studying the properties and reactions of indole derivatives, as well as for the development of new synthetic methods and applications in organic chemistry.
Used in Manufacturing Applications:
4-(TRIMETHYLSILYL)-1H-INDOLE 98 is used in the manufacturing process of various chemical products, taking advantage of its high purity and versatility as a building block for the synthesis of different compounds.

InChI:InChI=1/C11H15NSi/c1-13(2,3)11-6-4-5-10-9(11)7-8-12-10/h4-8,12H,1-3H3

Upstream product

• 120-72-9 indole 
• 52488-36-5 4-bromo-1H-indole 
• 75-77-4 chloro-trimethyl-silane 
• 83188-11-8 1,4-bis(trimethylsilyl)indole 
• 123191-00-4 1-(triisopropylsilyl)-1H-indole 
• 17983-42-5 trimethylsilyl indole 

Downstream Products

• 92013-04-2 1-Acetyl-6-chloroacetylindole 

Relevant academic research and scientific papers

The Direct C-4 Substitution of Indole; An X-Ray Crystal Structure Analysis of 4-(Trimethylsilyl)indole

Indole was converted into the 1,4-diacetyl and 1-acetyl-4-(3-chloropropanoyl) derivatives by direct C-4 electrophilic substitution via 4-(trimethylsilyl)indole (3c); the structure of (3c) was confirmed by a single crystal X-ray analysis.

Multinuclear NMR study of compounds resulting from the silylation of indole; evidence for a 4,5-disilylation

Complete assignments of the 1H, 13C and 29Si NMR data of 1-, 4- and 5-trimethylsilyl-, 1,4- and 1,5-bis(trimethylsilyl)- and 1,4,5-tris(trimethylsilyl)-indoles allowed unambiguous confirmation of the structures proposed for these products.For the trisilylated derivative it was found that silylation had occurred at the 1,4,5 and not at 1,4,7 positions as previously suggested.

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to antiviral agents. Specifically, the present invention relates to compounds of formula I which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL 6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for mating the compounds.

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

Preparation and Reactions of 4-(Trimethylsilyl)indole

Indole or 1-(trimethylsilyl)indole was reacted sequentially with lithium-chlorotrimethylsilane and with 1,4-benzoquinone to produce 1,4-bis(trimethylsilyl)indole (50 percent and 55 percent, respectively).Methanolysis gave 4-(trimethylsilyl)indole which reacted with electrophiles at C-3.However, the derivative 1-acetyl-4-(trimethylsilyl)indole reacted with acetyl, 2-chloropropanoyl, or propenoyl chlorides via clean C-4 ipso substitution.Attemps to extend the reaction to a useful synthesis of derivatives of 5-oxo-1,3,4,5-tetrahydrobenzindole, a lysergic acid synthon, were prevented by low yields.