92013-04-2 Usage
Properties and Specific Content of 1H-Indole, 1-acetyl-6-(chloroacetyl)(9CI)
A chemical compound consisting of 14 carbon atoms, 12 hydrogen atoms, 1 chlorine atom, 1 nitrogen atom, and 2 oxygen atoms.
2. Indole Derivative
A compound based on the indole structure, which is a bicyclic aromatic organic compound with a seven-membered ring and a six-membered ring connected together.
3. Acetyl Group at 1-Position
A functional group (-COCH3) attached to the first position of the indole ring, which contributes to the compound's chemical reactivity and properties.
4. Chloroacetyl Group at 6-Position
A functional group (-COCH2Cl) attached to the sixth position of the indole ring, which further influences the compound's reactivity and properties.
5. Usage in Organic Synthesis and Medicinal Chemistry
This chemical is often used as a building block or intermediate in the synthesis of more complex organic compounds, particularly in the development of pharmaceutical compounds.
6. Potential Antiviral, Antimicrobial, and Anticancer Activities
The compound has been studied for its possible therapeutic effects against viruses, bacteria, and cancer cells, making it a valuable research target in the field of medicinal chemistry.
7. Valuable Building Block for Synthesis of Biologically Active Molecules
Due to its unique structure and functional groups, 1H-Indole, 1-acetyl-6-(chloroacetyl)- (9CI) can be used to create other molecules with potential biological activity, making it an important tool in the development of new drugs and therapies.
8. Potential Hazards and Toxic Effects
As with any chemical compound, it is important to handle 1H-Indole, 1-acetyl-6-(chloroacetyl)(9CI) with care, as it may pose health risks or toxic effects if not properly managed.
Check Digit Verification of cas no
The CAS Registry Mumber 92013-04-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,0,1 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 92013-04:
(7*9)+(6*2)+(5*0)+(4*1)+(3*3)+(2*0)+(1*4)=92
92 % 10 = 2
So 92013-04-2 is a valid CAS Registry Number.
92013-04-2Relevant academic research and scientific papers
Regioselective acylations at the 2 and 6 position of N-acetylindole
Cruz, Rosimeire P.A.,Ottoni, Olívia,Abella, Carlos A.M.,Aquino, Lígia B.
, p. 1467 - 1469 (2007/10/03)
Regioselective acylations under Friedel-Crafts conditions at C6 and C2 positions of N-acetylindole are described.
FORMATION OF 6-ACYLINDOLES FROM 1-ACYLINDOLES
Nakatsuka, Shin-ishi,Teranishi, Katsunori,Goto, Toshio
, p. 2699 - 2700 (2007/10/02)
1-Acylindoles react regioselectively with α-halogenoacyl chloride in the presence of aluminum chloride to produce 1-acyl-6-halogenoacylindoles in excellent yields.
INDOLE DERIVATIVES. 131.* REACTION OF 1-ACYLINDOLES WITH ACETYLCHLORIDE AND CHLOROACETYLCHLORIDE UNDER FRIEDEL-CRAFTS CONDITIONS
Shner, V.F.,Sladkova, T.N.,Turchin, K.F.,Suvorov, N.N.
, p. 272 - 274 (2007/10/02)
Acylation of 1-acylindoles by acetylchloride and chloroacetylchloride in the presence of aluminium chloride leads to formation of 3-acetyl and 6-chloroacetyl-1-acylindoles, respectively.
Preparation and Reactions of 4-(Trimethylsilyl)indole
Barrett, Anthony G. M.,Dauzonne, Daniel,O'Neil, Ian A.,Renaud, Alain
, p. 4409 - 4415 (2007/10/02)
Indole or 1-(trimethylsilyl)indole was reacted sequentially with lithium-chlorotrimethylsilane and with 1,4-benzoquinone to produce 1,4-bis(trimethylsilyl)indole (50 percent and 55 percent, respectively).Methanolysis gave 4-(trimethylsilyl)indole which reacted with electrophiles at C-3.However, the derivative 1-acetyl-4-(trimethylsilyl)indole reacted with acetyl, 2-chloropropanoyl, or propenoyl chlorides via clean C-4 ipso substitution.Attemps to extend the reaction to a useful synthesis of derivatives of 5-oxo-1,3,4,5-tetrahydrobenzindole, a lysergic acid synthon, were prevented by low yields.
