827-46-3

Basic information

• Product Name: 2-phenyl-1,3-thiazol-4(5H)-one
• Synonyms: 2-Phenyl-1,3-thiazol-4(5H)-one; 4(5H)-thiazolone, 2-phenyl-
• CAS NO: 827-46-3
• Molecular Formula: C₉H₇NOS
• Molecular Weight: 177.223
• Mol File: 827-46-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 301.6°C at 760 mmHg
• Flash Point: 136.2°C
• Density: 1.29g/cm³
• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 2-phenyl-1,3-thiazol-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1,3-thiazol-4(5H)-one(827-46-3)
• EPA Substance Registry System: 2-phenyl-1,3-thiazol-4(5H)-one(827-46-3)

Safety Data

• Hazardous Substances Data: 827-46-3(Hazardous Substances Data)

Upstream product

• 79-11-8 chloroacetic acid 
• 2227-79-4 benzenecarbothioamide 
• 867-49-2 Chlorthioessigsaeure 
• 100-47-0 benzonitrile 
• 79-04-9 chloroacetyl chloride 
• 598-21-0 2-Bromoacetyl bromide 
• 96-32-2 bromoacetic acid methyl ester 
• 118987-79-4 4'-(tert-Butyl-dimethyl-silanyloxy)-2,2'-diphenyl-2,3-dihydro-[2,5']bithiazolyl-4-one 
• 118987-78-3 2-(4'-hydroxy-2'-phenylthiazol-5'-yl)-2-phenylthiazolidin-4-one 
• 68-11-1 mercaptoacetic acid 

Downstream Products

• 97819-41-5 5-[(5-Methyl-isoxazol-3-yl)-hydrazono]-2-phenyl-thiazol-4-one 
• 83492-20-0 5-(4-Methyl-quinolin-2-yl)-2-phenyl-thiazol-4-one 
• 83492-21-1 5-(4-Methoxy-quinolin-2-yl)-2-phenyl-thiazol-4-one 
• 83492-22-2 5-(4-Morpholin-4-yl-quinolin-2-yl)-2-phenyl-thiazol-4-one 

Relevant articles and documents

Enantioselective Construction of Spiro[chroman-thiazolones]: Bifunctional Phosphonium Salt-Catalyzed [2+4] Annulation between 5-Alkenyl Thiazolones and ortho-Hydroxyphenyl-Substituted para-Quinone Methides

The enantioselective formal [2+4] annulation of 5-alkenyl thiazolones with hydroxyl-substituted para-quinone methides was disclosed by dipeptide-based phosphonium salt catalysts. A wide range of functionalized spiro-chroman-thiazolone molecules bearing three contiguous 3° and/or 4° stereocenters were readily constructed in high yields with excellent stereoselectivities (>20:1 dr and up to >99.9% ee) under low catalyst loading and mild reaction conditions. The practicality and utility of this protocol were demonstrated by the scaled-up preparation and elaborations of product. (Figure presented.).

Thiazolo [2,3-b] oxazolone compound and preparation method and application thereof

The invention provides a compound shown in a formula I, or a salt thereof, or a stereoisomer thereof; R1 is selected from 3 and 8-element unsaturated cycloalkyl and 3 and 8-element unsaturated heterocyclic group; R2 is selected from hydrogen, C1-C8 alkyl

Crystal form of dihydropyranothiazole compound and preparation method thereof

The invention provides a crystal form I of a compound shown by formula (A). The crystal form I is characterized in that the crystal form is a triclinic system, wherein the space group is P1, and the cell parameters are shown in the description. The invent