827-46-3

Upstream product

• 79-11-8 chloroacetic acid 
• 2227-79-4 benzenecarbothioamide 
• 68-11-1 mercaptoacetic acid 
• 100-47-0 benzonitrile 
• 867-49-2 Chlorthioessigsaeure 
• 118987-78-3 2-(4'-hydroxy-2'-phenylthiazol-5'-yl)-2-phenylthiazolidin-4-one 
• 118987-79-4 4'-(tert-Butyl-dimethyl-silanyloxy)-2,2'-diphenyl-2,3-dihydro-[2,5']bithiazolyl-4-one 
• 96-32-2 bromoacetic acid methyl ester 
• 598-21-0 2-Bromoacetyl bromide 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 2080-26-4 3-acetyl-2-phenyl-2-(2-phenyl-thiazol-4-yloxy)-thiazolidin-4-one 
• 46414-55-5 4-acetoxy-2-phenylthiazole 
• 92795-17-0 5-benzylidene thiazolone 
• 2080-29-7 5-(anilino-phenyl-methylene)-2-phenyl-thiazol-4-one 
• 97819-41-5 5-[(5-Methyl-isoxazol-3-yl)-hydrazono]-2-phenyl-thiazol-4-one 
• 83492-30-2 5-(1-isoquinolyl)-2-phenyl-2-thiazolin-4-one 
• 83492-20-0 5-(4-Methyl-quinolin-2-yl)-2-phenyl-thiazol-4-one 
• 83492-23-3 5-(3-Bromo-quinolin-2-yl)-2-phenyl-thiazol-4-one 
• 83492-21-1 5-(4-Methoxy-quinolin-2-yl)-2-phenyl-thiazol-4-one 
• 83492-22-2 5-(4-Morpholin-4-yl-quinolin-2-yl)-2-phenyl-thiazol-4-one 

Relevant academic research and scientific papers

Enantioselective Construction of Spiro[chroman-thiazolones]: Bifunctional Phosphonium Salt-Catalyzed [2+4] Annulation between 5-Alkenyl Thiazolones and ortho-Hydroxyphenyl-Substituted para-Quinone Methides

The enantioselective formal [2+4] annulation of 5-alkenyl thiazolones with hydroxyl-substituted para-quinone methides was disclosed by dipeptide-based phosphonium salt catalysts. A wide range of functionalized spiro-chroman-thiazolone molecules bearing three contiguous 3° and/or 4° stereocenters were readily constructed in high yields with excellent stereoselectivities (>20:1 dr and up to >99.9% ee) under low catalyst loading and mild reaction conditions. The practicality and utility of this protocol were demonstrated by the scaled-up preparation and elaborations of product. (Figure presented.).

Organophosphane-catalyzed direct β-acylation of 4-arylidene pyrazolones and 5-arylidene thiazolones with acyl chlorides

An efficient method for the direct β-acylation of arylidene pyrazolones and thiazolones with acyl chlorides in the presence of a base catalyzed by organophosphanes is reported. A variety of functionalized 4-arylidene pyrazolone and 5-arylidene thiazolone derivatives were prepared under metal-free and mild conditions via a tandem phospha-Michael addition/O-acylation/intramolecular cyclization/rearrangement sequence. Our mechanistic investigations revealed that the reaction is highly stereospecific to provide exclusively cis-isomers, and the methodology can also be scaled up with similar efficacy.

Thiazolo [2,3-b] oxazolone compound and preparation method and application thereof

The invention provides a compound shown in a formula I, or a salt thereof, or a stereoisomer thereof; R1 is selected from 3 and 8-element unsaturated cycloalkyl and 3 and 8-element unsaturated heterocyclic group; R2 is selected from hydrogen, C1-C8 alkyl

Dihydopyranothiazole ring compound as well as preparation method and application thereof

The invention provides a dihydopyranothiazole ring compound shown as a formula (I) and further provides a preparation method for preparing the previous compound. The compound disclosed by the invention is simple and convenient in preparation method, mild

Crystal form of dihydropyranothiazole compound and preparation method thereof

The invention provides a crystal form I of a compound shown by formula (A). The crystal form I is characterized in that the crystal form is a triclinic system, wherein the space group is P1, and the cell parameters are shown in the description. The invent

Oxidative N-heterocyclic carbene catalyzed stereoselective annulation of simple aldehydes and 5-alkenyl thiazolones

A highly diastereoselective annulation of simple aldehydes and 5-alkenyl thiazolones, via oxidative NHC catalysis has been developed. This strategy provides facile access to a diverse library of functionalized chiral thiazolo pyrones. Aerobic oxygen can a

4-Hydroxythiazole Inhibitors of 5-Lipoxygenase

4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 μM.An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives.The corresponding thiazolidin-4-one analogues were found to be relatively inactive.The 4-hydroxythiazoles were active inhibitors against 5-lipoxygenase in both intact rat polymorphonuclear leukocytes and human whole blood.The compounds were also selective inhibitors of 5-lipoxygenase, displaying only weak activity against other related enzymes, cyclooxygenase and 12- and 15-lipoxygenase.

A NOVEL ONE-POT SYNTHESIS OF SUBSTITUTED 4-t-BUTYLDIMETHYLSILYLOXY-THIAZOLES

The reaction of 2-halo-acylimidazolides or halides with primary thioamides in base give 2-halo-N-acylthioamides, which cyclize to the substituted 4-thiazolones and are trapped as the novel 4-t-butyldimethylsilyloxythiazoles in fair to good yield.The 2-ary

A facile preparation of 4-thiazolone derivatives from thioamides and various haloacyl halides in a biphase system

The reaction of thioamides (1) with various haloacyl halides (2, 7, 11, 14, 17, and 19) was carried out in sat. NaHCO3-CH2Cl2 and 5% NaOH-CH2C12 to give several kinds of 4-thiazolones (3-5, 10, 12 and