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Usage

Uses

Used in Pharmaceutical Industry:
N-Acetyl2-bromo-5-chloroaniline is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique functional groups allow for versatile chemical reactions that can lead to the development of new and effective medications.
Used in Dye Industry:
In the dye industry, N-Acetyl2-bromo-5-chloroaniline is used as an intermediate in the production of dyes due to its capacity to contribute to the color and stability of the final dye products. Its presence in dye molecules can enhance their performance characteristics, such as colorfastness and solubility.
Used in Chemical and Industrial Processes:
N-Acetyl2-bromo-5-chloroaniline may have potential uses in various chemical and industrial processes, where its specific functional groups can be utilized for the development of new compounds or the improvement of existing processes. Its reactivity and intermediate role in synthesis make it a valuable component in these applications.
It is important to handle N-Acetyl2-bromo-5-chloroaniline with care due to its potentially hazardous properties, ensuring safety in its use across different industries.

Upstream product

• 614-76-6 N-acetyl-2-bromoaniline 
• 823-57-4 2-bromo-5-chloroaniline 
• 75-36-5 acetyl chloride 
• 41513-04-6 2-chloro-5-bromonitrobenzene 

Downstream Products

• 1006-99-1 2-methyl-5-chloro-benzothiazole 
• 708-73-6 7-chloro-2-methyl-4H-3,1-benzoxazin-4-one 
• 126759-61-3 1-(6-chloroindol-1-yl)ethanone 
• 126759-55-5 2-ethenyl-5-chloroacetanilide 

Relevant academic research and scientific papers

Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs can be constructed by this method.

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY

A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.

Fused heterotricyclic compounds as inhibitors of 17beta-hydroxysteroid dehydrogenase 3

Fused heterotricyclic compounds, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.