82725-38-0Relevant academic research and scientific papers
A novel method for preparing isocyanides from N-substituted formamides with chlorophosphate compounds
Kobayashi, Genki,Saito, Tateo,Kitano, Yoshikazu
experimental part, p. 3225 - 3234 (2011/11/30)
Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl2, EtOPOCl2, Me2NPOCl2, and (PhO)2POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides. Georg Thieme Verlag Stuttgart · New York.
Synthesis of 1-Aryl-4-methylthio-2-azetidinones
Wiatschka, Alexander,Ongania, Karl-Hans
, p. 593 - 602 (2007/10/02)
The N-arylthioformimidates 4a-e, which may be obtained by S-alkylation of the thioformanilides 3a-e, react with chloroacetylchloride/triethylamine to yield the (3R,4S/3S,4R)-1-aryl-3-chloro-4-methylthio-2-azetidinones 5a-e and the formanilides 6a-e.Dehalogenation of 5b-e with tri-n-butyltinhydride yield the title compounds 7b-e.Hydrogenolysis of 7b and 7c yields 7f and 7g. - Keywords: 1-Aryl-3-chloro-4-methylthio-2-azetidinones; 1-Aryl-4-methylthio-2-azetidinones; Dehalogenation; N-Arylthioformimidates; Tri-n-butyltinhydride
