82726-32-7

Upstream product

• 74-11-3 para-chlorobenzoic acid 
• 7568-93-6 2-Amino-1-phenylethanol 
• 122-78-1 phenylacetaldehyde 
• 104-86-9 4-chlorobenzylamine 
• 1826-13-7 5-phenylthiazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 591-50-4 iodobenzene 

Downstream Products

• 65752-46-7 4-acetoxy-2-(4-chloro-phenyl)-5-phenyl-thiazole 
• 65752-50-3 2-(4-chloro-phenyl)-5-phenyl-thiazol-4-one 
• 65752-41-2 2-(4-chloro-phenyl)-5-phenyl-thiazole 3-oxide 

Relevant academic research and scientific papers

Cu-Catalyzed Aerobic Oxidative Sulfuration/Annulation Approach to Thiazoles via Multiple Csp3-H Bond Cleavage

A novel and practical Cu-catalyzed aerobic oxidative synthesis of thiazoles was developed. This chemistry for the first time achieved thiazole construction from simple aldehydes, amines, and element sulfur through multiple Csp3-H bond cleavage processes. Molecular oxygen was used as a green oxidant in this oxidative protocol. The substrate scope is broad with the tolerance of aliphatic amines. The mechanistic study might promote the reaction design for a new sulfuration/annulation reaction with readily available element sulfur.

Programmed synthesis of arylthiazoles through sequential C-H couplings

A programmed synthesis of privileged arylthiazoles via sequential C-H couplings catalyzed by palladium or nickel catalysts has been accomplished. This versatile protocol can supply all possible arylthiazole substitution patterns (2-aryl, 4-aryl, 5-aryl, 2

Straightforward microwave-assisted synthesis of 2-thiazolines using Lawesson's reagent under solvent-free conditions

2-Thiazolines are synthesized from carboxylic acids and 1,2-aminoalcohols in the presence of Lawesson's reagent under solventless conditions. The developed method is valid for either substituted or unsubstituted aminoalcohols and a wide variety of aromatic, heteroaromatic and aliphatic carboxylic acids; thus it constitutes a general synthetic method for these kinds of compounds. The role of Lawesson's reagent is dual: to transform the 1,2-aminoalcohol into 1,2-aminothiol and to activate its reaction with the carboxylic acid leading to the formation of a thiazoline ring, all in one pot.