82924-17-2

Upstream product

• 72297-80-4 1-[((S)-3-iodo-2-methylpropoxy)methyl]benzene 
• 82924-16-1 1-(4-phenylbutyryl)-L-prolinol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 18496-54-3 phenylbutyric acid chloride 

Downstream Products

• 82924-18-3 ethyl (2R,4R)-5-(benzyloxy)-4-methyl-2-(2-phenylethyl)pentanoate 
• 82924-14-9 1-<(2R,4R)-4-(ethoxycarbonyl)-2-methyl-4-(2-phenylethyl)butyryl>indoline-2(S)-carboxylic acid 
• 82950-76-3 1-<(2R,4R)-4-carboxy-2-methyl-4-(2-phenylethyl)butyryl>indoline-2(S)-carboxylic acid 
• 82924-21-8 (2R,4R)-4-(ethoxycarbonyl)-2-methyl-4-(2-phenylethyl)butyryl chloride 
• 82924-20-7 ethyl hydrogen (2R,4R)-2-methyl-4-(2-phenylethyl)glutarate 
• 82924-19-4 ethyl (2R,4R)-5-hydroxy-4-methyl-2-(2-phenylethyl)pentanoate 

Relevant academic research and scientific papers

1-Carboxyalkanoylindoline-2-carboxylic acids

1-Carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acids, e.g., those of the formula STR1 R=H, alkyl, alkoxy, halogeno or CF3 ; R'=H or R-phenyl; m=0 or 1; p,q=0 to 2; and derivatives thereof, are antihypertensive and cardioactive agents.

Angiotensin Converting Enzyme Inhibitors: 1-Glutarylindoline-2-carboxylic Acid Derivatives

The preparation of a series of 1-glutarylindoline-2(S)-carboxylic acid derivatives, 6a-v and 21a-c, is described.The above compounds were tested for inhibition of angiotensin converting enzyme.The structure-activity relationship of the series is also discussed.Compound 6u, the most potent member of the series, had an in vitro IC50 of 4.8*10-9 M.Compound 6v, an ethyl ester of 6u, lowered blood pressure 70 mm in spontaneous hypertensive rats at an oral dose of 30 mg/kg.

1-CARBOXYALKANOYLINDOLINE-2-CARBOXYLIC ACIDS

1-Carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acids, e.g., those of the formula STR1 R=H, alkyl, alkoxy, halogeno or CF. sub.3 ; R'=H or R-phenyl;m=0 or 1;p, q=0 to 2; and functional derivatives thereof, are antihypertensive a