4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Base Information

Chemical Name:4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline
CAS No.:82925-02-8
Molecular Formula:C19H24N2O2
Molecular Weight:312.412
Hs Code.:2933499090
European Community (EC) Number:833-984-2
DSSTox Substance ID:DTXSID60434665
Nikkaji Number:J1.056.318F
Wikidata:Q82249136
Mol file:82925-02-8.mol

Synonyms:82925-02-8;4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline;4-[2-(6,7-Dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]aniline;4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]aniline;4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]-benzenamine;4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine;4-(2-(6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLIN-2(1H)-YL)ETHYL)BENZENAMINE);4-[2-(6,7-dimethoxy-3,4-dihydro-1h-isoquinolin-2-yl)-ethyl]-phenylamine;4-[2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]aniline;SCHEMBL2771882;DTXSID60434665;AMY32343;MFCD04974539;AKOS000814157;AC-13016;AS-40405;CS-0006980;FT-0650587;A840474;F9995-0459;Benzenepropanoic acid, 4-fluoro-.beta.-oxo-, ethyl ester;4-[2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolinyl)ethyl]aniline;4-(2-(6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-yl)-ethyl)-benzenamine;4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl]benzenamine;4-[2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-yl)ethyl]benzenamine;benzenamine,4-(2-(3,4-dihydro-6,7-dimethoxy-2(1h)-isoquinolinyl)ethyl)-

Suppliers and Price of 4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine
100mg
$ 80.00

TRC
4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine
1g
$ 110.00

SynChem
4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenylamine 95+%
5 g
$ 1150.00

SynChem
4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenylamine 95+%
1 g
$ 450.00

Crysdot
4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline 95+%
5g
$ 535.00

Chemenu
4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline 95%
5g
$ 505.00

Biosynth Carbosynth
4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine
5 g
$ 625.00

Biosynth Carbosynth
4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine
500 mg
$ 120.00

Biosynth Carbosynth
4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine
2 g
$ 300.00

Biosynth Carbosynth
4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine
1 g
$ 188.00

Total 28 raw suppliers

Chemical Property of 4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:129 °C
Refractive Index:1.592
Boiling Point:473.704 °C at 760 mmHg
PKA:8.00±0.20(Predicted)
Flash Point:240.288 °C
PSA：47.72000
Density:1.132 g/cm³
LogP:3.40590
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Soluble in dichloromethane, ethyl acetate and methanol.
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:312.183778013
Heavy Atom Count:23
Complexity:357

Purity/Quality:

97% ^*data from raw suppliers

4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]benzenamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)N)OC
Uses It is an intermediate for the preparation of Elacridar. Intermediate for the preparation of Elacridar

Technology Process of 4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline

There total 11 articles about 4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 82925-01-7
1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[2-(4-nitrophenyl)ethyl]-isoquinoline

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 18h; under 760.051 Torr;

Reference yield: 88.0%

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

Guidance literature:

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

Guidance literature:: Multi-step reaction with 2 steps

1: 14.5 g / K₂CO₃ / dimethylformamide / 6 h / 100 °C

2: H₂ / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a017