82971-75-3

Upstream product

• 67-56-1 methanol 
• 51461-47-3 3-benzyl-3-hydroxy-2-phenylisoindolin-1-one 
• 64-17-5 ethanol 
• 95733-67-8 3-Anilino-3-benzyl-2-phenylphtalimidine 
• 15310-01-7 benodanil 
• 536-74-3 phenylacetylene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 86770-00-5 (E)-N-phenyl-2-styrylbenzamide 
• 5079-90-3 (E)-2-styrylbenzoic acid 
• 204847-93-8 trans-stilbene-2-carbonyl chloride 
• 575-61-1 Isoaurone 
• 33148-55-9 2-(2-phenylacetyl)benzoic acid 
• 4767-56-0 (Z)-3-benzylidenephthalide 
• 62-53-3 aniline 

Relevant academic research and scientific papers

Direct Difluorination-Hydroxylation, Trifluorination, and C(sp2)-H Fluorination of Enamides

A direct double functionalization involving both difluorination and hydroxylation of enamides is reported. With the appropriate combination of an electrophilic fluorinating reagent and H2O, the most convenient and ecofriendly hydroxylating agent, the preparation of 3-(difluoroalkyl)-3-hydroxyisoindolin-1-ones was achieved under basic or Br?nsted acidic conditions. Suitable conditions for trifluorination as well as C(sp2)-H fluorination were also identified. Subsequent asymmetric functionalization of the obtained gem-difluorinated products has also been demonstrated.

An Easy-to-Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization

Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.

Dichotomous control of E/Z-geometry in intramolecular cyclization of o-alkynylbenzamide derivatives catalyzed by organic superbase P4-tBu in the presence/absence of water

E/Z does it! An intramolecular cycli-zation reaction of o-alkynylbenzamides that allows dichotomous control of E/Z-geometry has been developed using an organic superbase, P4-tBu, as a catalyst. The presence/absence of water along with the use of an organi

Preparation of 3-Hydroxyindolin-1-ones and o-Acylbenzamides. A Study of Ring-Chain Tautomerism

3-Hydroxyisoindolinones (ring form) as well as their chain tautomers, o-acylbenzamides, were prepared from the reactions of 3-benzalphthalide 1, 3-halophthalides 3, and o-acylbenzoic acids 6 or their esters 7 with amines 2, and those of phthalimides 4 wit