82971-76-4Relevant academic research and scientific papers
Palladium/Copper-Catalyzed Denitrogenative Alkylidenation and ortho-Alkynylation Reaction of 1,2,3-Benzotriazin-4(3 H)-ones
Hari Balakrishnan, Madasamy,Mannathan, Subramaniyan
supporting information, p. 542 - 546 (2020/02/04)
An efficient palladium-catalyzed approach to access various functionalized (Z)-3-benzylidene-isoindoline-1-ones and (Z)-3-benzylidene(imino)isobenzofuranones via a denitrogenative tandem alkynylation/cyclization reaction of 1,2,3-benzotriazin-4(3H)-ones w
A ligand-free approach to substituted (Z)-3-methyleneisoindolin-1-ones via Cu (I) catalyzed regio- and stereo-selective assembly of 2-iodo benzamide and terminal alkyne
De, Rimpa,Bera, Mrinal K.
supporting information, p. 1780 - 1789 (2020/05/29)
A ligand-free and cost-effective synthesis of substituted 3-methyleneisoindolin -1-ones from 2-iodobenzamide and terminal alkyne under copper (I)-catalyzed condition was accomplished. The reaction affords excellent yield of the product at a relatively low
A Cu-catalysed synthesis of substituted 3-methyleneisoindolin-1-one
Gogoi, Anupal,Guin, Srimanta,Rout, Saroj K.,Majji, Ganesh,Patel, Bhisma K.
, p. 59902 - 59907 (2015/02/19)
A Cu(I)-catalysed synthesis of substituted 3-methyleneisoindolin-1-ones using alkynyl acids as an alkyne source has been developed. The reaction involves the decarboxylative cross-coupling of 2-halobenzamides with aryl alkynyl acids, followed by 5-exo-dig
Copper(II)-catalyzed tandem synthesis of substituted 3-methyleneisoindolin- 1-ones
Pan, Jie,Xu, Zhen,Zeng, Runsheng,Zou, Jianping
supporting information, p. 1022 - 1026 (2013/09/02)
An efficient strategy for the synthesis of a variety of 3-methyleneisoindolin-1-ones has been developed. The reaction proceeded from coupling of 2-iodobenzamides (or 2-bromobenzamides) and terminal alkynes via Cu(OAc)2·H2O/2,2′-biimi
Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)2·H2O/DBU under Microwave Irradiation
Zhang, Li,Zhang, Yongliang,Wang, Xin,Shen, Jingkang
, p. 654 - 665 (2013/03/14)
Microwave-promoted efficient synthesis of a (Z)-3-methyleneisoindolin-1-one library from 2-bromobenzamides and terminal alkynes using Cu(OAc) 2·H2O/DBU is described. Various benzamide substituents, ring substitutions, including heter
A green approach for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones in aqueous medium
Chatterjee, Nivedita,Sarkar, Swarbhanu,Pal, Rammyani,Sen, Asish Kumar
supporting information, p. 3748 - 3751 (2013/07/05)
A high yielding novel methodology was developed for the regio- and stereo-selective syntheses of (Z)-3-methyleneisoindoline-1-ones from substituted 2-phenylethynyl benzamides, generated in situ from 2-(phenylcarbamoyl)phenyl-1- H-imidazole-1-sulfonates and corresponding alkyne by Cu-free Sonogashira cross-coupling-5-exo-dig-cyclization in aqueous medium under sonication. The compound could easily be purified by recrystallization from EtOAc without column chromatography.
A novel approach for highly regio- and stereoselective synthesis of (Z)-3-methyleneisoindoline-1-ones in aqueous micellar medium
Sarkar, Swarbhanu,Dutta, Samrat,Dey, Rajdip,Naskar, Subhendu
supporting information, p. 6789 - 6792 (2013/01/15)
An environmentally benign and operationally simple methodology was developed for the regio- and stereoselective synthesis of (Z)-3- methyleneisoindolinones in aqueous micellar medium from 2-iodo-N-phenyl- benzamides and terminal alkyne by Cu-free domino S
Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: Access to 3-(phenylmethylene)isoindolin-1- ones and related heterocycles
Hellal, Malik,Cuny, Gregory D.
supporting information; experimental part, p. 5508 - 5511 (2011/10/31)
An efficient microwave assisted one-pot synthesis of substituted 3-(phenylmethylene)isoindolin-1-ones is reported via a copper-free Sonogashira coupling and a regioselective 5-exo-dig cycloisomerization. This domino reaction was also extended to other related heterocycles.
Assembly of substituted 3-methyleneisoindolin-1-ones via a cul/l-proline-catalyzed domino reaction process of 2-bromobenzamides and terminal alkynes
Li, Li,Wang, Miao,Zhang, Xiaojing,Jiang, Yongwen,Ma, Dawei
supporting information; experimental part, p. 1309 - 1312 (2009/08/07)
Cul/L-proline catalyzed coupling of 2-bromobenzamides and terminal alkynes in i-Pr0H (or DMF and DMSO) at 85-110 °C and subsequent additive cyclization produces substituted 3-methyleneisoindolin-1-ones. Variation of N-substituents, aromatic ring, and meth
Dichotomous control of E/Z-geometry in intramolecular cyclization of o-alkynylbenzamide derivatives catalyzed by organic superbase P4-tBu in the presence/absence of water
Kanazawa, Chikashi,Terada, Masahiro
supporting information; experimental part, p. 1668-1672+1637 (2010/07/03)
E/Z does it! An intramolecular cycli-zation reaction of o-alkynylbenzamides that allows dichotomous control of E/Z-geometry has been developed using an organic superbase, P4-tBu, as a catalyst. The presence/absence of water along with the use of an organi
